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The thymus (pl.: thymuses or thymi) is a specialized primary lymphoid organ of the immune system. Within the thymus, thymus cell lymphocytes or T cells mature. T cells are critical to the adaptive immune system, where the body adapts to specific foreign invaders. The thymus is located in the upper front part of the chest, in the anterior ...
The primary (or central) lymphoid organs, including the thymus, bone marrow, fetal liver and yolk sac, are responsible for generating lymphocytes from immature progenitor cells in the absence of antigens. [12] The thymus and the bone marrow constitute the primary lymphoid organs involved in the production and early clonal selection of ...
Various bird organs function to differentiate avian immune cells: the thymus, Bursa of Fabricius and bone marrow are primary avian lymphoid organs whereas the spleen, mucosal associated lymphoid tissues (MALT), germinal centers, and diffuse lymphoid tissues are secondary lymphoid organs. As a general rule, birds do not have lymph nodes.
The thymus is a primary lymphoid organ of the immune system. It is a butterfly-shaped organ consisting of two lobes, located in the top part of the chest, that supports T cell development via specialized microenvironments that ensure a diverse, functional, and self-tolerant T cell population.
In mammals, B cells mature in the bone marrow and T cells mature in the thymus. [1] Central tolerance is not perfect, so peripheral tolerance exists as a secondary mechanism to ensure that T and B cells are not self-reactive once they leave primary lymphoid organs.
H&E stain. Hassall's corpuscles (also known as thymic bodies) are structures found in the medulla of the human thymus, formed from eosinophilic type VI thymic epithelial cells arranged concentrically. These concentric corpuscles are composed of a central mass, consisting of one or more granular cells, and of a capsule formed of epithelioid cells.
Thymic epithelial cells (TECs) are specialized cells with high degree of anatomic, phenotypic and functional heterogeneity that are located in the outer layer (epithelium) of the thymic stroma. The thymus, as a primary lymphoid organ, mediates T cell development and maturation. The thymic microenvironment is established by TEC network filled ...
The red bone marrow is a key element of the lymphatic system, being one of the primary lymphoid organs that generate lymphocytes from immature hematopoietic progenitor cells. [24] The bone marrow and thymus constitute the primary lymphoid tissues involved in the production and early selection of lymphocytes.