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Five main classes of agents can be used to treat hyperlipidemia, a condition that comes with high cholesterol levels. Those are bile acid sequestrants, nicotinic acid, fibric acid derivatives, probucol and HMG-CoA-reductase inhibitors. Cerivastatin mainly acts by competitively inhibiting HMG-CoA-reductase, which is the rate-limiting enzyme step ...
Statins have been studied for improving operative outcomes in cardiac and vascular surgery. [42] Mortality and adverse cardiovascular events were reduced in statin groups. [43] Older adults who receive statin therapy at time of discharge from the hospital after an inpatient stay have been studied. People with cardiac ischemia not previously on ...
From 1996 to 2012, under the trade name Lipitor, atorvastatin became the world's best-selling medication of all time, with more than $125 billion in sales over approximately 14.5 years. [119] and $13 billion a year at its peak, [120] Lipitor alone "provided up to a quarter of Pfizer Inc.'s annual revenue for years." [119]
When examining the cost-effectiveness of statin use in older adults, the researchers report that statins were cost-effective, with the cost per quality-adjusted life years gained below £3,502 ...
SAAM may affect people after long-term statin use even if they had no previous muscular side effects. [4] A differentiating feature between this and more benign statin side effects is SAAM typically has a late onset. While muscle pain (myalgia) is seen in 9-20% of patients treated with statins, it typically occurs in the first month of treatment.
While COVID hospitalizations and deaths are up this winter, JN.1 itself may not be to blame. ... and a cold tends to cause a slight cough. However, you can have any of the four conditions without ...
As with all statin drugs, it can occasionally cause myopathy, hepatotoxicity (liver damage), dermatomyositis or rhabdomyolysis. [9] This can be life-threatening if not recognised and treated in time, so any unexplained muscle pain or weakness whilst on lovastatin should be promptly mentioned to the prescribing doctor.
The following rare side effects are more serious. Like all statins, rosuvastatin can possibly cause myopathy, rhabdomyolysis: [14] [4] muscle pain, tenderness, or weakness; lack of energy; fever; chest pain; jaundice: yellowing of the skin or eyes; dark colored, or foamy urine; pain in the upper right part of the abdomen; nausea; extreme ...