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A neuromuscular junction (or myoneural junction) is a chemical synapse between a motor neuron and a muscle fiber. [1] It allows the motor neuron to transmit a signal to the muscle fiber, causing muscle contraction. [2] Muscles require innervation to function—and even just to maintain muscle tone, avoiding atrophy.
In biology, a motor unit is made up of a motor neuron and all of the skeletal muscle fibers innervated by the neuron's axon terminals, including the neuromuscular junctions between the neuron and the fibres. [1] Groups of motor units often work together as a motor pool to coordinate the contractions of a single muscle.
Structure of neuromuscular junction. A neuromuscular junction is a chemical synapse formed by the contact between a motor neuron and a muscle fiber. [17] It is the site in which a motor neuron transmits a signal to a muscle fiber to initiate muscle contraction.
In general, cellular response to stimuli is defined as a change in state or activity of a cell in terms of movement, secretion, enzyme production, or gene expression. [9] Receptors on cell surfaces are sensing components that monitor stimuli and respond to changes in the environment by relaying the signal to a control center for further ...
Glutamate released from the upper motor neurons triggers depolarization in the lower motor neurons in the anterior grey column, which in turn causes an action potential to propagate the length of the axon to the neuromuscular junction where acetylcholine is released to carry the signal across the synaptic cleft to the postsynaptic receptors of the muscle cell membrane, signaling the muscle to ...
The movement of the axons (and subsequently the Schwann cells) is guided by the growth cone, a filamentous projection of the axon that actively searches for neurotrophins released by the myotube. [33] The specific patterning of synapse development at the neuromuscular junction shows that the majority of muscles are innervated at their midpoints.
A neuroeffector junction is a site where a motor neuron releases a neurotransmitter to affect a target—non-neuronal—cell. This junction functions like a synapse . However, unlike most neurons, somatic efferent motor neurons innervate skeletal muscle, and are always excitatory.
The space between the nerve terminal and the muscle cell is called the neuromuscular junction. These neurotransmitters diffuse across the synapse and bind to specific receptor sites on the cell membrane of the muscle fiber. When enough receptors are stimulated, an action potential is generated and the permeability of the sarcolemma is altered ...