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The immortal DNA strand hypothesis was proposed in 1975 by John Cairns as a mechanism for adult stem cells to minimize mutations in their genomes. [1] This hypothesis proposes that instead of segregating their DNA during mitosis in a random manner, adult stem cells divide their DNA asymmetrically, and retain a distinct template set of DNA strands (parental strands) in each division.
Serine/threonine-protein kinase ATR, also known as ataxia telangiectasia and Rad3-related protein (ATR) or FRAP-related protein 1 (FRP1), is an enzyme that, in humans, is encoded by the ATR gene. [5] [6] It is a large kinase of about 301.66 kDa. [7] ATR belongs to the phosphatidylinositol 3-kinase-related kinase protein family.
The Journal of Stem Cells & Regenerative Medicine is an open-access online scientific journal. It is the official journal of the German Society for Stem Cell Research (GSZ) and publishes research articles focusing on stem cells and regenerative medicine and related fields.
An improved system, which was the first nucleic acid device to make use of toehold-mediated strand displacement, was demonstrated by Bernard Yurke in 2000. [9] The next advance was to translate this into mechanical motion, and in 2004 and 2005, several DNA walker systems were demonstrated by the groups of Seeman, Niles Pierce , Andrew ...
Stem Cells and Development is a biweekly peer-reviewed scientific journal covering cell biology, with a specific focus on biomedical applications of stem cells. It was established in 1992 as the Journal of Hematotherapy, and was renamed the Journal of Hematotherapy & Stem Cell Research in 1999. The journal obtained its current name in 2004. [1]
It covers contemporary and emerging areas in stem cells, including embryonic and adult stem cells, and related lineage and cloning issues. The journal also publishes reviews covering basic, clinical, biotechnology, regulatory, and ethical aspects of stem cell research and applications. [1] The journal got its current name in 2009 from Stem Cell ...
Expert Review of Medical Devices is a monthly peer-reviewed medical journal covering research on the clinical use of devices. It was established in 2004 and is published by Informa . According to the Journal Citation Reports , the journal has a 2013 impact factor of 1.784.
Stem-loops are nucleic acid secondary structural elements which form via intramolecular base pairing in single-stranded DNA or RNA. They are also referred to as hairpins or hairpin loops. A stem-loop occurs when two regions of the same nucleic acid strand, usually complementary in nucleotide sequence, base-pair to form a double helix that ends ...