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Hyperandrogenism, especially high levels of testosterone, can cause serious adverse effects if left untreated. High testosterone levels are associated with other health conditions such as obesity, hypertension, amenorrhea (cessation of menstrual cycles), and ovulatory dysfunction, which can lead to infertility.
[122] [126] High doses or levels of AAS, including testosterone, can cause polycythemia—high red blood cell and/or hemoglobin levels that increase the risk of stroke—as an adverse effect. [121] [122] Conversely, whether via castration, NSAA monotherapy, or CAB, decreased erythropoiesis resulting in mild anemia is a common side effect of ADT ...
Polycythemia is often asymptomatic; patients may not experience any notable symptoms until their red cell count is very high. For patients with significant elevations in hemoglobin or hematocrit (often from polycythemia vera), some non-specific symptoms include: [9] A ruddy (red) complexion, or plethora [12]
It may also lead to abnormally high levels of androgens, which can cause hirsutism. ... 5% weight loss could lower testosterone levels and insulin resistance markers. ... and hemoglobin markers ...
Dips in testosterone can cause low libido, brain fog, depression, and muscle loss, but it's pivotal you know your normal range, a doctor says.
The pharmacology of bicalutamide is the study of the pharmacodynamic and pharmacokinetic properties of the nonsteroidal antiandrogen (NSAA) bicalutamide.In terms of pharmacodynamics, bicalutamide acts as a selective antagonist of the androgen receptor (AR), the biological target of androgens like testosterone and dihydrotestosterone (DHT).
A booming industry of men's health clinics offers men in their 20s, 30s, and 40s testosterone therapy to optimize their bodies. Doctors are skeptical. Young men are getting testosterone boosts to ...
Testosterone, via its active metabolite 3α-androstanediol, is a potent positive allosteric modulator of the GABA A receptor. [150] Testosterone has been found to act as an antagonist of the TrkA and p75 NTR, receptors for the neurotrophin nerve growth factor (NGF), with high affinity (around 5 nM).