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  2. Runs of homozygosity - Wikipedia

    en.wikipedia.org/wiki/Runs_of_Homozygosity

    Runs of homozygosity (ROH) are contiguous lengths of homozygous genotypes that are present in an individual due to parents transmitting identical haplotypes to their offspring. [ 1 ] The potential of predicting or estimating individual autozygosity for a subpopulation is the proportion of the autosomal genome above a specified length, termed F ...

  3. Inbred strain - Wikipedia

    en.wikipedia.org/wiki/Inbred_strain

    However, for some experiments, genetic diversity in the test population may be desired. Thus outbred strains of most laboratory animals are also available, where an outbred strain is a strain of an organism that is effectively wildtype in nature, where there is as little inbreeding as possible. [2]

  4. Inbreeding - Wikipedia

    en.wikipedia.org/wiki/Inbreeding

    However, increased homozygosity increases the probability of fixing beneficial alleles and also slightly decreases the probability of fixing deleterious alleles in a population. [9] Inbreeding can result in purging of deleterious alleles from a population through purifying selection. [10] [11] [12] Inbreeding is a technique used in selective ...

  5. Hardy–Weinberg principle - Wikipedia

    en.wikipedia.org/wiki/Hardy–Weinberg_principle

    Fisher's exact test can be applied to testing for Hardy–Weinberg proportions. Since the test is conditional on the allele frequencies, p and q, the problem can be viewed as testing for the proper number of heterozygotes. In this way, the hypothesis of Hardy–Weinberg proportions is rejected if the number of heterozygotes is too large or too ...

  6. F1 hybrid - Wikipedia

    en.wikipedia.org/wiki/F1_hybrid

    Inbreeding and selection for uniformity for multiple generations ensures that the parent lines are almost homozygous. The divergence between the (two) parent lines promotes improved growth and yield characteristics in offspring through the phenomenon of heterosis ("hybrid vigour" or "combining ability").

  7. Inbreeding avoidance - Wikipedia

    en.wikipedia.org/wiki/Inbreeding_avoidance

    Inbreeding avoidance, or the inbreeding avoidance hypothesis, is a concept in evolutionary biology that refers to the prevention of the harmful effects of inbreeding. Animals only rarely exhibit inbreeding avoidance. [ 1 ]

  8. Zygosity - Wikipedia

    en.wikipedia.org/wiki/Zygosity

    The words homozygous, heterozygous, and hemizygous are used to describe the genotype of a diploid organism at a single locus on the DNA. Homozygous describes a genotype consisting of two identical alleles at a given locus, heterozygous describes a genotype consisting of two different alleles at a locus, hemizygous describes a genotype consisting of only a single copy of a particular gene in an ...

  9. Partial dominance hypothesis - Wikipedia

    en.wikipedia.org/wiki/Partial_dominance_hypothesis

    In genetics, the partial dominance hypothesis states that inbreeding depression is the result of the frequency increase of homozygous deleterious recessive or partially recessive alleles. The hypothesis can be explained by looking at a population that is divided into a large number of separately inbred lines.