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Hyperpolarization machines are currently being used to develop hyperpolarized xenon gas that is used as a visualization agent for the lungs. Xenon-129 is a safe inert noble gas that can be used to quantify lung function. With a single 10-second breath hold, hyperpolarized Xenon-129 is used with MRI to enable 3-dimensional lung imaging. [35]
Hyperpolarized carbon-13 MRI is a functional medical imaging technique for probing perfusion and metabolism using injected substrates.. It is enabled by techniques for hyperpolarization of carbon-13-containing molecules using dynamic nuclear polarization and rapid dissolution to create an injectable solution.
The hyperpolarization creates a large signal intensity, and the wide range of chemical shifts allows for identifying when the 129 Xe associates with molecules like hemoglobin. 129 Xe is preferred over 131 Xe for MRI because 129 Xe has spin 1/2 (compared to 3/2 for 131 Xe), a longer T1 , and 3.4 times larger gyromagnetic ratio (11.78 MHz/T).
Hyperpolarized gas MRI, also known as hyperpolarized helium-3 MRI or HPHe-3 MRI, is a medical imaging technique that uses hyperpolarized gases to improve the sensitivity and spatial resolution of magnetic resonance imaging (MRI).
Dynamic nuclear polarization (DNP) is one of several hyperpolarization methods developed to enhance the sensitivity of nuclear magnetic resonance (NMR) spectroscopy.While an essential analytical tool with applications in several fields, NMR’s low sensitivity poses major limitations to analyzing samples with low concentrations and limited masses and volumes. [1]
Hyperpolarization is a change in membrane potential. Neuroscientists measure it using a technique known as patch clamping that allows them to record ion currents passing through individual channels. This is done using a glass micropipette, also called a patch pipette, with a 1 micrometer diameter.
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A polarized 3D system uses polarization glasses to create the illusion of three-dimensional images by restricting the light that reaches each eye (an example of stereoscopy). To present stereoscopic images and films, two images are projected superimposed onto the same screen or display through different polarizing filters .