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Estradiol benzoate: 0.5 mg 1x/week: 1 mg 1x/week: 1.5 mg 1x/week SC implant: Estradiol: 25 mg 1x/6 months: 50 mg 1x/6 months: 100 mg 1x/6 months Footnotes: a = No longer used or recommended, due to health concerns. b = As a single patch applied once or twice per week (worn for 3–4 days or 7 days), depending on the formulation.
Estradiol levels with 50 to 100 μg/day transdermal estradiol patches applied to the forearm and to the scrotum in a crossover study in 2 men with prostate cancer. [14] In 35 men treated continuously with one 100 μg/day estradiol patch scrotally, the mean estradiol level was ~500 pg/mL (range ~125–1,200 pg/mL).
Available transdermal estradiol patches in the United States [1] [2] [a] Brand name Dose (µg/day) DOA (d) Size [b] [c] (cm 2) Levels (pg/mL) Intro. Alora [3] [4] 25, 50, 75, 100 3–4 9, 18, 27, 36 43–144 1996 Climara [d] [5] [6] 25, 37.5, 50, 60, 75, 100 7 6.5, 9.375, 12.5, 15, 18.75, 25 17–174 1994 Climara Pro [e] [7] [8] E2 (45)
Estrogen: SC implant: 50–200 mg every 6–24 mos Estradiol valerate: Progynova: Estrogen: Oral: 2–10 mg/day Progynova: Estrogen: Sublingual: 1–8 mg/day Delestrogen [c] Estrogen: IM, SC: 2–10 mg/wk or 5–20 mg every 2 wks Estradiol cypionate: Depo-Estradiol: Estrogen: IM, SC: 2–10 mg/wk or 5–20 mg every 2 wks Estradiol dipropionate ...
Trough estradiol levels and MADRS Tooltip Montgomery–Åsberg Depression Rating Scale scores with 1 mg sublingual micronized estradiol 3 to 8 times per day (3 to 8 mg/day total; mean 4.8 mg/day total) in women with postpartum depression. [8] Blood was drawn specifically in the mornings before the first dose of sublingual estradiol for the day. [8]
Dosage Ref(s) Oral: Estradiol: ... Transdermal patch: Estradiol: 2–6x 100 μg/day ... Template:Estrogen dosages for breast cancer; Template:Estrogen dosages for ...
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