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In humans, the SRY gene is located on short (p) arm of the Y chromosome at position 11.2. Sex-determining region Y protein (SRY), or testis-determining factor (TDF), is a DNA-binding protein (also known as gene-regulatory protein/transcription factor) encoded by the SRY gene that is responsible for the initiation of male sex determination in therian mammals (placentals and marsupials). [5]
The human Y chromosome showing the SRY gene which codes for a protein regulating sexual differentiation. Sexual differentiation in humans is the process of development of sex differences in humans . It is defined as the development of phenotypic structures consequent to the action of hormones produced following gonadal determination. [ 1 ]
The tip of the Y chromosome contains the SRY gene and, during recombination, a translocation occurs in which the SRY gene becomes part of the X chromosome. [15] [26] If a fetus is conceived from a sperm cell with an X chromosome bearing the SRY gene, it will develop as a male despite not having a Y chromosome. This form of the condition is ...
There is a gene in the Y chromosome that has regulatory sequences that control genes that code for maleness, called the SRY gene. [8] This gene produces a testis-determining factor ("TDF"), which initiates testis development in humans and other mammals. The SRY sequence's prominence in sex determination was discovered when the genetics of sex ...
6657 20674 Ensembl ENSG00000181449 ENSMUSG00000074637 UniProt P48431 P48432 RefSeq (mRNA) NM_003106 NM_011443 RefSeq (protein) NP_003097 NP_035573 Location (UCSC) Chr 3: 181.71 – 181.71 Mb Chr 3: 34.7 – 34.71 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse SRY (sex determining region Y)-box 2, also known as SOX2, is a transcription factor that is essential for maintaining self ...
Sexual differentiation is the process of development of the sex differences between males and females from an undifferentiated zygote. [1] [2] Sex determination is often distinct from sex differentiation; sex determination is the designation for the development stage towards either male or female, while sex differentiation is the pathway towards the development of the phenotype.
SOX genes (SRY-related HMG-box genes) encode a family of transcription factors that bind to the minor groove in DNA, and belong to a super-family of genes characterized by a homologous sequence called the HMG-box (for high mobility group). This HMG box is a DNA binding domain that is highly conserved throughout eukaryotic species.
The SHOX gene in the PAR1 region is the gene most commonly associated with and well understood with regards to disorders in humans, [17] but all pseudoautosomal genes escape X-inactivation and are therefore candidates for having gene dosage effects in sex chromosome aneuploidy conditions (45,X, 47,XXX, 47,XXY, 47,XYY, etc.).