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Wilms' tumor or Wilms tumor, [3] also known as nephroblastoma, is a cancer of the kidneys that typically occurs in children (rarely in adults), [4] and occurs most commonly as a renal tumor in child patients. [5] [6] It is named after Max Wilms, the German surgeon (1867–1918) who first described it. [7]
WAGR syndrome (also known as WAGR complex, Wilms tumour-aniridia syndrome, aniridia-Wilms tumour syndrome) is a rare genetic syndrome in which affected children are predisposed to develop Wilms' tumour (a tumour of the kidneys), aniridia (absence of the coloured part of the eye, the iris), genitourinary anomalies, and mental retardation. [1]
This is an accepted version of this page This is the latest accepted revision, reviewed on 21 February 2025. Medical condition Kidney cancer Other names Renal cancer Micrograph showing the most common type of kidney cancer (clear cell renal cell carcinoma). H&E stain. Specialty Oncology nephrology Urology Symptoms Blood in the urine, lump in the abdomen, back pain Usual onset After the age of ...
Embryonal tumor (e.g., Wilms tumor, hepatoblastoma, neuroblastoma, rhabdomyosarcoma) in childhood; Visceromegaly involving one or more intra-abdominal organs including liver, spleen, kidneys, adrenal glands, and/or pancreas; Cytomegaly of the fetal adrenal cortex (pathognomonic)
Medical imaging, such as abdominal ultrasound, may be used to distinguish a Sister Mary Joseph nodule from another kind of mass. [ 2 ] Gastrointestinal malignancies account for about half of underlying sources (most commonly gastric cancer , colonic cancer or pancreatic cancer , mostly of the tail and body of the pancreas [ 3 ] ), and men are ...
The cause of DDS is most commonly (96% of patients) an abnormality in the WT1 gene (Wilms tumor suppressor gene). These abnormalities include changes in certain exons (9 and 8) and mutations in some alleles of the WT1 gene. Genetically, the syndrome is due to mutations in the Wilms tumor suppressor gene, WT1, which is on chromosome 11 (11p13 ...
Wilms tumor (5%, kidney) Non-Hodgkin lymphoma (4%, blood) Childhood rhabdomyosarcoma (3%, many sites) Retinoblastoma (3%, eye) Osteosarcoma (3%, bone cancer) Ewing sarcoma (1%, many sites) Germ cell tumors (5%, many sites) Pleuropulmonary blastoma (lung or pleural cavity) Hepatoblastoma and hepatocellular carcinoma (liver cancer) Juvenile ...
Like any elevated tumor marker, elevated AFP by itself is not diagnostic, only suggestive. Tumor markers are used primarily to monitor the result of a treatment (e.g. chemotherapy). If levels of AFP go down after treatment, the tumor is not growing. In the case of babies, after treatment AFP should go down faster than it would normally. A ...