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Olanzapine occupancy at 5-HT 2A receptor are high at all doses (5 mg to 20 mg). It is reported that 5 mg dose of olanzapine produced a mean occupancy of 85% at 5 mg, 88% at 10 mg, and 93% at 20 mg dose . [95] Olanzapine had the highest affinity of any second-generation antipsychotic towards the P-glycoprotein in one in vitro study. [96]
"Time to peak" refers to when maximum levels of the drug in the blood occur after a given dose. ... Typical Oral Dosage Formulations (mg) ... 30 20-25: 1–1.5: 40–250:
Very common adverse effects of olanzapine, occurring more than 10%, include: Weight gain (dose-dependent). Weight gain of over 7% of a person's initial body weight prior to treatment is in this category of very common too with some estimates of its incidence putting it at around 40.6%.
Mianserin at higher doses (30–90 mg/day) is used for the treatment of major depressive disorder. [ 6 ] It can also be used at lower doses (around 10 mg/day) to treat insomnia.
Olanzapine: 20–30% [75] 0–15% [75] 20-30% [75] ... C max (ng/mL) Amisulpride: Oral: 12: 5.8 ... 10.7 (single 4 mg dose), 12 (single 8 mg dose), 16.2 (single 12 mg ...
[3] [25] A recent 2024 study found that using high doses of antipsychotics for schizophrenia was linked to a higher risk of mortality. [30] Researchers analyzed data from 32,240 individuals aged 17 to 64 diagnosed with schizophrenia between 2002 and 2012 to arrive at this conclusion. [31]
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