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B cell activation: from immature B cell to plasma cell or memory B cell Basic B cell function: bind to an antigen, receive help from a cognate helper T cell, and differentiate into a plasma cell that secretes large numbers of antibodies. B cell activation occurs in the secondary lymphoid organs (SLOs), such as the spleen and lymph nodes. [1]
10673 24099 Ensembl ENSG00000102524 ENSMUSG00000031497 UniProt Q9Y275 Q9WU72 RefSeq (mRNA) NM_001145645 NM_006573 NM_033622 NM_001347309 RefSeq (protein) NP_001139117 NP_006564 NP_001334238 NP_296371 Location (UCSC) Chr 13: 108.25 – 108.31 Mb Chr 8: 10.06 – 10.09 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse B-cell activating factor (BAFF) also known as tumor necrosis factor ...
The B cells develop dynamically after the activation of follicular B cells by T-dependent antigen. The initiation of germinal center formation involves the interaction between B and T cells in the interfollicular area of the lymph node, CD40-CD40L ligation, NF-kB signaling and expression of IRF4 and BCL6. [4]
In humans, CD27 is a good marker for plasma cells; naïve B cells are CD27−, memory B-cells are CD27+ and plasma cells are CD27++. [5] The surface antigen CD138 (syndecan-1) is expressed at high levels. [6] Another important surface antigen is CD319 (SLAMF7). This antigen is expressed at high levels on normal human plasma cells.
A B-cell receptor includes both CD79 and the immunoglobulin. The plasma membrane of a B cell is indicated by the green phospholipids. The B- cell receptor extends both outside the cell (above the plasma membrane) and inside the cell (below the membrane). The B-cell receptor (BCR) is a transmembrane protein on the surface of a B cell.
Complement receptor 2 interacts with CD19, [7] [8] and, on mature B cells, forms a complex with CD81 (TAPA-1). The CR2-CD19-CD81 complex is often called the B cell co-receptor complex, [9] because CR2 binds to opsonized antigens through attached C3d (or iC3b or C3dg) when the B-cell receptor binds antigen. This results in the B cell having ...
CD79 serves to be a pan-B cell marker for the detection of B-cell neoplasms.However, tumor cells in some cases of T-lymphoblastic leukemia/lymphoma and AML has shown to potentially react positively with CD79 monoclonal antibodies. [4]
BCGFs specifically mediate the growth and division of B cells, or, in other words, the progression of B cells through their life cycle (cell cycle stages G1, S, G2). BCDFs control the advancement of a B cell progenitor or unmatured B cell to an adult immunoglobulin (Ig) secreting cell. Differentiation factors control cell fate and can sometimes ...