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22227 Ensembl ENSG00000109424 ENSMUSG00000031710 UniProt P25874 P12242 RefSeq (mRNA) NM_021833 NM_009463 RefSeq (protein) NP_068605 NP_033489 Location (UCSC) Chr 4: 140.56 – 140.57 Mb Chr 8: 84.02 – 84.03 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Thermogenin (called uncoupling protein by its discoverers and now known as uncoupling protein 1, or UCP1) is a mitochondrial ...
Structure of the human uncoupling protein UCP1. An uncoupling protein (UCP) is a mitochondrial inner membrane protein that is a regulated proton channel or transporter.An uncoupling protein is thus capable of dissipating the proton gradient generated by NADH-powered pumping of protons from the mitochondrial matrix to the mitochondrial intermembrane space.
In 2023, the Home Office said it could not determine any legitimate industrial uses for DNP in the United Kingdom. [14] It is a chemical intermediate in the production of sulfur dyes, [3] wood preservatives [9] and picric acid. [15] A precursor to 2,4,6-trinitrotoluene (TNT), DNP has also been used to make photographic developers and explosives.
An uncoupler or uncoupling agent is a molecule that disrupts oxidative phosphorylation in prokaryotes and mitochondria or photophosphorylation in chloroplasts and cyanobacteria by dissociating the reactions of ATP synthesis from the electron transport chain.
In practice the efficiency may be even lower because the inner membrane of the mitochondria is slightly leaky to protons. [16] Other factors may also dissipate the proton gradient creating an apparently leaky mitochondria. An uncoupling protein known as thermogenin is expressed in some cell types and is a channel that can transport protons.
Limiting certain foods may also help in controlling high blood pressure. First, individuals with hypertension are recommended to limit sodium intake to about 1,500 milligrams or less per day.
Metabolism (/ m ə ˈ t æ b ə l ɪ z ə m /, from Greek: μεταβολή metabolē, "change") is the set of life-sustaining chemical reactions in organisms.The three main functions of metabolism are: the conversion of the energy in food to energy available to run cellular processes; the conversion of food to building blocks of proteins, lipids, nucleic acids, and some carbohydrates; and the ...
Inositol or its phosphates and associated lipids are found in many foods, in particular fruit, especially cantaloupe and oranges. [17] In plants, the hexaphosphate of inositol, phytic acid or its salts, the phytates, serve as phosphate stores in seed, for example in nuts and beans. [18] Phytic acid also occurs in cereals with high bran content.