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Pernicious anemia is the most common cause of vitamin B 12 deficiency anemia in adults, which results from malabsorption of vitamin B 12 due to a lack or loss of intrinsic factor. [2] [8] There are relatively few studies which have assessed the impact of haematological measures in response to B 12 supplementation.
Pernicious anemia is the most common cause of clinically evident vitamin B 12 deficiency worldwide. [14] Pernicious anemia due to autoimmune problems occurs in about one per 1000 people in the US. Among those over the age of 60, about 2% have the condition. [8] It more commonly affects people of northern European descent. [2]
Deficiency isn't common, but can produce some scary side effects when it does happen. Lack of vitamin B12 can cause megaloblastic anemia —a condition characterized by larger than normal red ...
The most common cause of vitamin B 12 deficiency in developed countries is impaired absorption due to a loss of gastric intrinsic factor (IF) which must be bound to a food source of B 12 for absorption to occur. [11]
Most Americans get plenty of vitamin B12 through the food they eat, but there are some notable exceptions (older Americans are particularly at risk, because they have less intrinsic factor, with ...
“The most common manifestation of B12 deficiency is fatigue.” That fatigue and related symptoms can be confused with symptoms of depression and dementia, he says.
The B 12 vitamin is not abundantly available from plant products [4] (although it has been found in moderate abundance in fermented vegetable products, certain seaweeds, and in certain mushrooms, with the bioavailability of the vitamin in these cases remaining uncertain), [5] making B 12 deficiency a legitimate concern for those maintaining a ...
Common, most foods do not contain vitamin D, indicating that a deficiency will occur unless people get sunlight exposure or eat manufactured foods purposely fortified with vitamin D. Vitamin D deficiency is a known cause of rickets, and has been linked to numerous other health problems.