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Ronald Fisher. Sir Ronald Aylmer Fisher FRS [5] (17 February 1890 – 29 July 1962) was a British polymath who was active as a mathematician, statistician, biologist, geneticist, and academic. [6][7] For his work in statistics, he has been described as "a genius who almost single-handedly created the foundations for modern statistical science ...
The Genetical Theory of Natural Selection is a book by Ronald Fisher which combines Mendelian genetics with Charles Darwin's theory of natural selection, [1] with Fisher being the first to argue that "Mendelism therefore validates Darwinism" [2] and stating with regard to mutations that "The vast majority of large mutations are deleterious; small mutations are both far more frequent and more ...
United States. "The Correlation between Relatives on the Supposition of Mendelian Inheritance"[1] is a scientific paper by Ronald Fisher which was published in the Transactions of the Royal Society of Edinburgh in 1918, (volume 52, pages 399–433). In it, Fisher puts forward the "infinitesimal model", a genetics conceptual model showing that ...
The Human Genome Project was a 13 year-long publicly funded project initiated in 1990 with the objective of determining the DNA sequence of the entire euchromatic human genome within 13 years. [8] [9] The idea of such a project originated in the work of Ronald A. Fisher, whose work is also credited with later initiating the project. [10]
Fisher's fundamental theorem of natural selection is an idea about genetic variance [1] [2] in population genetics developed by the statistician and evolutionary biologist Ronald Fisher. The proper way of applying the abstract mathematics of the theorem to actual biology has been a matter of some debate, however, it is a true theorem.
The work of Fisher, Haldane and Wright founded the discipline of population genetics. This integrated natural selection with Mendelian genetics, which was the critical first step in developing a unified theory of how evolution worked. [4] [5] John Maynard Smith was Haldane's pupil, whilst W. D. Hamilton was
Fisher's geometric model. Fisher's geometric model (FGM) is an evolutionary model of the effect sizes and effect on fitness of spontaneous mutations [1] proposed by Ronald Fisher to explain the distribution of effects of mutations that could contribute to adaptative evolution. [2]
The infinitesimal model, also known as the polygenic model, is a widely used statistical model in quantitative genetics and in genome-wide association studies.Originally developed in 1918 by Ronald Fisher, it is based on the idea that variation in a quantitative trait is influenced by an infinitely large number of genes, each of which makes an infinitely small (infinitesimal) contribution to ...