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Large granular lymphocytic (LGL) leukemia is a chronic lymphoproliferative disorder that exhibits an unexplained, chronic (> 6 months) elevation in large granular lymphocytes (LGLs) in the peripheral blood. [1] It is divided in two main categories: T-cell LGL leukemia (T-LGLL) and natural-killer (NK)-cell LGL leukemia (NK-LGLL).
Large granular lymphocytic leukemia may involve either T-cells or NK cells; like hairy cell leukemia, which involves solely B cells, it is a rare and indolent (not aggressive) leukemia. [26] Adult T-cell leukemia is caused by human T-lymphotropic virus (HTLV), a virus similar to HIV. Like HIV, HTLV infects CD4+ T-cells and replicates within ...
Its morphology is identical to that of precursor B-cell lymphoblastic leukemia. [1] Cell markers include TdT, CD2, CD7. [1] It often presents as a mediastinal mass because of involvement of the thymus. [1] It is highly associated with NOTCH1 mutations. [1] Other types include: Large granular lymphocytic leukemia; Adult T-cell leukemia/lymphoma
T-cell leukemia describes several different types of lymphoid leukemia which affect T cells. Types include: [1] Large granular lymphocytic leukemia; Adult T-cell leukemia/lymphoma; T-cell prolymphocytic leukemia; In practice, it can be hard to distinguish T-cell leukemia from T-cell lymphoma, and they are often grouped together.
Aggressive NK-cell leukemia is a disease with an aggressive, systemic proliferation of natural killer cells (NK cells) and a rapidly declining clinical course. [ 1 ] [ 2 ] [ 3 ] It is also called aggressive NK-cell lymphoma .
Chronic lymphocytic leukemia (CLL) is a type of cancer that affects the blood and bone marrow. [8] [9] In CLL, the bone marrow makes too many lymphocytes, which are a type of white blood cell. [8] [9] In patients with CLL, B cell lymphocytes can begin to collect in their blood, spleen, lymph nodes, and bone marrow.
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