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Renal artery stenosis (RAS) is the narrowing of one or both of the renal arteries, most often caused by atherosclerosis or fibromuscular dysplasia. This narrowing of the renal artery can impede blood flow to the target kidney , resulting in renovascular hypertension – a secondary type of high blood pressure .
This leads to a build-up of plaques and they can be deposited in the renal arteries causing stenosis and ischemic kidney disease. [citation needed] In this situation, the kidney supplied blood by the narrowed renal artery suffers from inadequate blood flow, which in turn causes the size of the kidneys to decrease. Other consequences include ...
Stenosis (from Ancient Greek στενός (stenós) 'narrow') is the abnormal narrowing of a blood vessel or other tubular organ or structure such as foramina and canals. It is also sometimes called a stricture (as in urethral stricture ).
The latter include renal artery stenosis, or the narrowing of the renal artery which supplies the kidney with blood, and renal vein thrombosis, which is the formation of a blood clot in the renal vein that drains blood from the kidney. [10]: 26-27
Angiotension converting enzyme. The pathogenesis of renovascular hypertension involves the narrowing of the arteries supplying the kidneys which causes a low perfusion pressure that is detected by the juxtaglomerular apparatus (via the macula densa cells, which act as baroreceptors; located on the afferent arteriole wall). [6]
Cardiorenal Syndrome is characterized by the dysfunction of both the cardiac and renal systems, resulting in a range of clinical manifestations. Many patients will have volume overload and therefore may show clinical signs such as jugular venous distension, generalized swelling of the abdomen and/or the lower legs, and difficulty breathing.
The renal arteries are paired arteries that supply the kidneys with blood. Each is directed across the crus of the diaphragm, so as to form nearly a right angle. The renal arteries carry a large portion of total blood flow to the kidneys. Up to a third of total cardiac output can pass through the renal arteries to be filtered by the kidneys.
Atherosclerotic obstruction of the renal artery can be treated with angioplasty with or without stenting of the renal artery. [10] There is a weak recommendation for renal artery angioplasty in patients with renal artery stenosis and flash edema or congestive heart failure. [10]