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A man with pellagra, which is caused by a chronic lack of vitamin B 3 in the diet. Severe deficiency of niacin in the diet causes the disease pellagra, characterized by diarrhea, sun-sensitive dermatitis involving hyperpigmentation and thickening of the skin (see image), inflammation of the mouth and tongue, delirium, dementia, and if left untreated, death. [7]
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Pellagra is a disease caused by a lack of the vitamin niacin (vitamin B 3). [2] Symptoms include inflamed skin, diarrhea, dementia, and sores in the mouth. [1] Areas of the skin exposed to friction and radiation are typically affected first. [1] Over time affected skin may become darker, stiffen, peel, or bleed. [1] [3]
Conrad Arnold Elvehjem (May 27, 1901 – July 27, 1962) was internationally known as an American biochemist in nutrition.In 1937 he identified two vitamins, nicotinic acid, also known as niacin, and nicotinamide, [1] which were deficient directly in human pellagra, once a major health problem in the United States. [2]
Nicotinamide (INN, BAN UK [2]) or niacinamide (USAN US) is a form of vitamin B 3 found in food and used as a dietary supplement and medication. [3] [4] [5] As a supplement, it is used orally (swallowed by mouth) to prevent and treat pellagra (niacin deficiency). [4]
Example of a label showing the amount of niacin (Vitamin B3), and specifying to be niacinamide in the ingredient section.. The United States adopted in 1942 the terms niacin to nicotinic acid and niacinamide to nicotinamide to avoid references to nicotine, [12] [13] the terms were incorporated into the United States Adopted Name [14] that was created later in 1961.
Single-dose administration of up to 500 mg was shown safe in men in a study at Keio University. [10] One 2021 clinical trial found that NMN improved muscular insulin sensitivity in prediabetic women, [ 11 ] while another found that it improved aerobic capacity in amateur runners. [ 12 ]
In the United States, a multivitamin/mineral supplement is defined as a supplement containing three or more vitamins and minerals that does not include herbs, hormones, or drugs, where each vitamin and mineral is included at a dose below the tolerable upper intake level as determined by the Food and Drug Board, and does not present a risk of ...