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Let’s talk 5mg finasteride vs 1mg—two different doses, one powerful hair loss treatment. Finasteride is the active ingredient in Propecia®, an oral medication that’s clinically-proven to ...
[4] [3] At steady-state with 1 mg/day finasteride, mean peak concentrations of finasteride were 9.2 ng/mL (25 nmol/L). [4] Conversely, following a single 5 mg dose of finasteride, mean peak levels of finasteride were 37 ng/mL (99 nmol/L), and plasma concentrations increased by 47–54% following 2.5 weeks of continued daily administration. [3]
As a treatment for benign prostatic hyperplasia (BPH), finasteride is used at a dosage of 5 mg per day. This dose can be found in generic forms of finasteride and the brand-name medication Proscar.
There were no differences in the rates of depression, self-harm, and suicide between finasteride and dutasteride, suggesting that the specific 5-ARI used does not influence the risks. [ 33 ] [ 21 ] [ 34 ] The absolute risks of self-harm and depression with 5-ARIs remain low (0.14% and 2.0%, respectively).
Structure of finasteride. Finasteride mainly inhibits the 5α-R2 (IC50=69 nM) and 5α-R3 (IC50=17.4 nM) with little inhibition of 5α-R1 (IC50=360 nM). As mentioned above, finasteride reduces prostatic DHT levels on a 70-90% range but the detailed reduction of DHT is 70.8% and 85% of intraprostatic DHT. [6]
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