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If a melanocytic nevus is suspected of being a melanoma, it needs to be sampled or removed via skin biopsy, and sent for microscopic evaluation by a pathologist. Depending on the size and location of the original nevus, a complete excisional skin biopsy or a punch skin biopsy can be done. Removal can also occur by shaving.
However, a melanocytic nevus is benign, and melanoma is malignant. Most melanocytic nevi never evolve into a cancer, with the lifetime risk for an individual nevus being 1 in 3000 for men and 1 in 11 000 for women. [5] Moreover, dermatologists have a standardized system for determining whether a skin lesion is suspicious for malignant melanoma.
Nevi and melanomas are a group of neoplasia. Although a nevus and a melanoma are often treated as independent entities, there is evidence that a nevus can be a precursor for a melanoma. [1] Common mutations have been identified in nevi and melanomas. [2] [3] [4]
Melanocytic nevi and neoplasms are caused by either a proliferation of (1) melanocytes, or (2) nevus cells, a form of melanocyte that lack dendritic processes. [78] [79] Acral nevus (melanocytic nevus of acral skin, melanocytic nevus with intraepidermal ascent of cells) Amelanotic blue nevus (hypomelanotic blue nevus) Becker's nevus; Balloon ...
Pseudomelanoma (also known as a "recurrent melanocytic nevus", [1] and "recurrent nevus" [2]) is a cutaneous condition in which melanotic skin lesions clinically resemble a superficial spreading melanoma at the site of a recent shave removal of a melanocytic nevus.
Inherited dysplastic nevus syndrome is an autosomal dominant hereditary condition. Dysplastic nevi are more likely to undergo malignant transformation when they occur among members of melanoma families. At least one study indicates a cumulative lifetime risk of nearly 100% in individuals who have dysplastic nevi and are members of melanoma ...
Neurocutaneous melanosis is associated with the presence of either giant congenital melanocytic nevi or non-giant nevi of the skin. It is estimated that neurocutaneous melanosis is present in 2% to 45% of patients with giant congenital melanocytic nevi. Patients with non-giant congenital melanocytic nevi seem to have a much lower, but undefined ...
Nevus cells are a variant of melanocytes. [1]: 684 They are larger than typical melanocytes, do not have dendrites, and have more abundant cytoplasm with coarse granules. [2] They are usually located at the dermoepidermal junction or in the dermis of the skin. Dermal nevus cells can be further classified: type A (epithelioid) dermal nevus cells ...