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Clozapine N-oxide (CNO) is a synthetic drug used mainly in biomedical research as a ligand to activate Designer Receptors Exclusively Activated by Designer Drugs (DREADDs), [1] despite the initial belief that it was biologically inert.
A stability derivative. This is an example of a common shorthand notation for stability derivatives. The "M" indicates it is a measure of pitching moment changes. The indicates the changes are in response to changes in angle of attack.
Clozapine, sold under the brand name Clozaril among others, is a psychiatric medication and was the first atypical antipsychotic to be discovered. [6] It is primarily used to treat people with schizophrenia and schizoaffective disorder who have had an inadequate response to two other antipsychotics, or who have been unable to tolerate other drugs due to extrapyramidal side effects.
Active noise control (ANC), also known as noise cancellation (NC), or active noise reduction (ANR), is a method for reducing unwanted sound by the addition of a second sound specifically designed to cancel the first.
A reverberation chamber is used to test the sound absorption coefficients and NRC of a material. The noise reduction coefficient (commonly abbreviated NRC) is a single number value ranging from 0.0 to 1.0 that describes the average sound absorption performance of a material.
Celexa – an antidepressant of the SSRI class; Centrax – an anti-anxiety agent; Clozaril – atypical antipsychotic used to treat resistant schizophrenia; Concerta (methylphenidate) – an extended release form of methylphenidate
N-Desmethylclozapine (NDMC), or norclozapine, is a major active metabolite of the atypical antipsychotic drug clozapine. [1] [2]Unlike clozapine, it possesses intrinsic activity at the D 2 /D 3 receptors, and acts as a weak partial agonist at these sites similarly to aripiprazole and bifeprunox. [3]
This ratio is therefore a comparison of the solubilities of the solute in these two liquids. The partition coefficient generally refers to the concentration ratio of un-ionized species of compound, whereas the distribution coefficient refers to the concentration ratio of all species of the compound (ionized plus un-ionized). [1]