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Hereditary cancer syndromes underlie 5 to 10% of all cancers and there are over 50 identifiable hereditary forms of cancer. [5] Scientific understanding of cancer susceptibility syndromes is actively expanding: additional syndromes are being found, [6] the underlying biology is becoming clearer, and genetic testing is improving detection, treatment, and prevention of cancer syndromes. [7]
Hereditary cancers are primarily caused by an inherited genetic defect. A cancer syndrome or family cancer syndrome is a genetic disorder in which inherited genetic mutations in one or more genes predisposes the affected individuals to the development of cancers and may also cause the early onset of these cancers. Although cancer syndromes ...
Hereditary nonpolyposis colorectal cancer (HNPCC) is a hereditary predisposition to colon cancer.. HNPCC includes (and was once synonymous with) [1] Lynch syndrome, an autosomal dominant genetic condition that is associated with a high risk of colon cancer, endometrial cancer (second most common), ovary, stomach, small intestine, hepatobiliary tract, upper urinary tract, brain, and skin. [2]
7428 22346 Ensembl ENSG00000134086 ENSMUSG00000033933 UniProt P40337 P40338 RefSeq (mRNA) NM_000551 NM_198156 NM_001354723 NM_009507 RefSeq (protein) NP_000542 NP_937799 NP_001341652 NP_000542.1 NP_033533 Location (UCSC) Chr 3: 10.14 – 10.15 Mb Chr 6: 113.6 – 113.61 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The Von Hippel–Lindau tumor suppressor also known as pVHL is a ...
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Typically, many genetic changes are required before cancer develops. [11] Approximately 5–10% of cancers are due to inherited genetic defects. [12] Cancer can be detected by certain signs and symptoms or screening tests. [2] It is then typically further investigated by medical imaging and confirmed by biopsy. [13]