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  2. Antithyroid autoantibodies - Wikipedia

    en.wikipedia.org/wiki/Antithyroid_autoantibodies

    Most antibodies produced are directed to conformational epitopes of the immunogenic carboxyl-terminal region of the TPO protein, although antibodies to linear epitopes have been seen. [4] Anti-TPO antibodies are the most common anti-thyroid autoantibody, present in approximately 90% of Hashimoto's thyroiditis , 75% of Graves' disease and 10 ...

  3. Thyroid peroxidase - Wikipedia

    en.wikipedia.org/wiki/Thyroid_peroxidase

    Thyroid peroxidase is a frequent epitope of autoantibodies in autoimmune thyroid disease, with such antibodies being called anti-thyroid peroxidase antibodies (anti-TPO antibodies). This is most commonly associated with Hashimoto's thyroiditis. Thus, an antibody titer can be used to assess disease activity in patients that have developed such ...

  4. Antithyroid agent - Wikipedia

    en.wikipedia.org/wiki/Antithyroid_agent

    These two markers are an elevated level of thyroid stimulating hormone receptor antibodies (TSHR-Ab) and smoking. A positive TSHR-Ab at the end of antithyroid drug treatment increases the risk of recurrence to 90% (sensitivity 39%, specificity 98%), a negative TSHR-Ab at the end of antithyroid drug treatment is associated with a 78% chance of ...

  5. Hashimoto's thyroiditis - Wikipedia

    en.wikipedia.org/wiki/Hashimoto's_thyroiditis

    It is not established that reducing antithyroid antibodies in Hashimoto's has benefits. [98] [15] [101] A systematic review and meta-analysis of selenium trials found that while selenium reduces TPO antibodies, there was a lack of evidence of effects on "disease remission, progression, lowered levothyroxine dose or improved quality of life". [8]

  6. Anti-histone antibodies - Wikipedia

    en.wikipedia.org/wiki/Anti-histone_antibodies

    Anti-histone antibodies are autoantibodies that are a subset of the anti-nuclear antibody family, which specifically target histone protein subunits or histone complexes. [1] They were first reported by Henry Kunkel , H.R. Holman, and H.R.G. Dreicher in their studies of cellular causes of lupus erythematosus in 1959–60.

  7. List of therapeutic monoclonal antibodies - Wikipedia

    en.wikipedia.org/wiki/List_of_therapeutic...

    This list of over 500 monoclonal antibodies includes approved and investigational drugs as well as drugs that have been withdrawn from market; consequently, the column Use does not necessarily indicate clinical usage. See the list of FDA-approved therapeutic monoclonal antibodies in the monoclonal antibody therapy page.

  8. Type IV hypersensitivity - Wikipedia

    en.wikipedia.org/wiki/Type_IV_hypersensitivity

    Hashimoto's thyroiditis [2] Thyroglobulin antigen Hypothyroidism, hard goiter, follicular thymitis Inflammatory bowel disease [2] Enteric microbiota and/or self antigens Hyperactivation of T-cells, cytokine release, recruitment of macrophages and other immune cells, inflammation Multiple sclerosis [2] Myelin antigens (e.g., myelin basic protein)

  9. Hashimoto's encephalopathy - Wikipedia

    en.wikipedia.org/wiki/Hashimoto's_encephalopathy

    Hashimoto's encephalopathy, also known as steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT), is a neurological condition characterized by encephalopathy, thyroid autoimmunity, and good clinical response to corticosteroids.

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