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L-α-Glycerophosphorylcholine (alpha-GPC, choline alfoscerate, sn-glycero-3-phosphocholine) is a natural choline compound found in the brain. It is also a parasympathomimetic acetylcholine precursor [ 1 ] which has been investigated for its potential for the treatment of Alzheimer's disease [ 2 ] and other dementias .
Paraoxon and rivastigmine are both acetylcholinesterase inhibitors and butyrylcholinesterase inhibitors. [14] [11] [7]In 2015, the United States Food and Drug Administration's Adverse Event Reporting System database compared rivastigmine to the other ChEI drugs donepezil and galantamine found that rivastigmine was associated with a higher frequency of reports of death as an adverse event.
Alpha GPC; Cisapride; Droperidol; Domperidone; Metoclopramide; Risperidone; Paliperidone; Anti-adrenergics: See also alpha blocker and beta blocker. Clonidine (α-receptor agonist, α 2 > α 1, giving negative feedback) Methyldopa (α 2 agonist, giving negative feedback) Propranolol (β-receptor antagonist) Metoprolol (β-receptor antagonist ...
Alpha-GPC – L-alpha glycerylphosphorylcholine has been studied only in the context of cognitive performance alongside other substances such as caffeine. [35] Choline bitartrate – Choline bitartrate is a tartaric acid salt containing choline (41% choline by molecular weight). One meta-analysis found choline bitartrate to be ineffective at ...
The name Belladonna, meaning beautiful ladies, was derived from women using berry juice from the plant cosmetically to dilate their pupils. [ 4 ] The mydriatic effect was studied by the German chemist Friedlieb Ferdinand Runge (1795-1867), in which the active ingredient, atropine , was first discovered by Vaquelin in 1809 and was first isolated ...
Muscarinic antagonist effects and muscarinic agonist effects counterbalance each other for homeostasis. Certain muscarinic antagonists can be classified into either long-acting muscarinic receptor antagonists ( LAMA s) or short-acting muscarinic receptor antagonists ( SAMA s), depending on when maximum effect occurs and for how long the effect ...