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An mRNA vaccine is a type of vaccine that uses a copy of a molecule called messenger RNA (mRNA) to produce an immune response. [1] The vaccine delivers molecules of antigen -encoding mRNA into cells , which use the designed mRNA as a blueprint to build foreign protein that would normally be produced by a pathogen (such as a virus ) or by a ...
A nucleoside-modified messenger RNA (modRNA) is a synthetic messenger RNA (mRNA) in which some nucleosides are replaced by other naturally modified nucleosides or by synthetic nucleoside analogues. [ 1 ] modRNA is used to induce the production of a desired protein in certain cells.
The Pfizer–BioNTech COVID-19 vaccine was the first mRNA vaccine approved by a medicines regulator, followed by the Moderna COVID-19 vaccine, and others. The main types of RNA therapeutics are those based on messenger RNA (mRNA), antisense RNA (asRNA), RNA interference (RNAi), and RNA aptamers.
Two pioneering scientists who created the technology behind life-saving Covid-19 vaccines have won the Nobel Prize in medicine or physiology.
A major advantage of mRNA therapies is the breakneck speed at which tailored treatments can be designed and produced. “It really only takes days to design a new mRNA vaccine,” Blakney said.
The original 2020 formula for mRNA vaccines required ultra-frozen storage conditions, up to -25 degrees Celsius, and both Moderna and competitor duo Pfizer and BioNTech were eventually able to ...