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Lubiprostone, sold under the brand name Amitiza among others, is a medication used in the management of chronic idiopathic constipation, predominantly irritable bowel syndrome-associated constipation in women and opioid-induced constipation. The drug is owned by Mallinckrodt and is marketed by Takeda Pharmaceutical Company.
Plecanatide, sold under the brand name Trulance, is a medication for the treatment of chronic idiopathic constipation (CIC) [4] and irritable bowel syndrome with constipation. [5] It is available in India under the brand name Plectide (OQM Div, MSN Laboratories, India).
These side effects may occur in as many as 90% of men treated with bicalutamide monotherapy, [29] but gynecomastia is generally reported to occur in 70 to 80% of patients. [30] In the EPC trial, at a median follow-up of 7.4 years, breast pain and gynecomastia respectively occurred in 73.6% and 68.8% of men treated with 150 mg/day bicalutamide ...
U.S. Food and Drug Administration Grants Priority Review Status to AMITIZA ® (lubiprostone) Submission Seeking Approval for Treatment of Opioid-induced Constipation BETHESDA, Md. & DEERFIELD, Ill ...
AMITIZA is approved in the United States for the treatment of two constipation-related indications, and in Switzerland and the United Kingdom for one constipation-related indication.
Eluxadoline is a μ-and κ-opioid receptor agonist and δ-opioid receptor antagonist [12] that acts locally in the enteric nervous system, possibly decreasing adverse effects on the central nervous system. [13] [14]