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Actoprotectors or synthetic adaptogens are compounds that enhance an organism's resilience to physical stress without increasing heat output. [1] Actoprotectors are distinct from other performance-enhancing substances in that they increase physical and psychological resilience via non-exhaustive action. [ 1 ]
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The term "adaptogen" refers to non-toxic plants or their extracts purported to diminish stress and support overall wellbeing when consumed. [4] However, the definition of an adaptogen is vague and without adequate scientific evidence, making it impossible to determine what exactly makes a substance an adaptogen.
Limited clinical studies have found that supplementation with various ashwagandha extracts may decrease anxiety and perceived stress, and improve sleep. [ 3 ] [ 4 ] [ 16 ] As the studies used different extract preparations, durations of use, doses, and types of subjects, how ashwagandha may have effects in people remains undetermined, as of 2023.
Adaptogens are plants that support health through nonspecific effects, neutralize various environmental and physical stressors while being relatively safe and free of side effects. [33] As of 2008, the position of the European Medicines Agency was that "The principle of an adaptogenic action needs further clarification and studies in the pre ...
Protandim is a herbal dietary supplement marketed with unsupported claims that it can treat a number of medical conditions. The product is a patented [1] mix of five herbal ingredients and sold by LifeVantage Corporation (formerly LifeLine Therapeutics, Lifeline Nutraceuticals, and Yaak River Resources, Inc), a Utah-based multi-level marketing company. [2]
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