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Lithium orotate (C 5 H 3 LiN 2 O 4) is a salt of orotic acid and lithium.It is available as the monohydrate, LiC 5 H 3 N 2 O 4 ·H 2 O. [1] In this compound, lithium is non-covalently bound to an orotate ion, rather than to a carbonate or other ion, and like other salts, dissolves in solution to produce free lithium ions.
Lithium – Lithium is the "classic" mood stabilizer, the first to be approved by the US FDA, and still popular in treatment. Therapeutic drug monitoring is required to ensure lithium levels remain in the therapeutic range: 0.6 to 0.8 or 0.8–1.2 mEq/L (or millimolar).
Orotic acid is a Bronsted acid and its conjugate base, the orotate anion, is able to bind to metals. Lithium orotate, for example, has been investigated for use in treating alcoholism, [4] [5] and complexes of cobalt, manganese, nickel, and zinc are known. [6]
7), lithium sulfate, lithium chloride, and lithium orotate. [ 139 ] [ 140 ] Nanoparticles and microemulsions have also been invented as drug delivery mechanisms. As of 2020, there is a lack of evidence that alternate formulations or salts of lithium would reduce the need for monitoring serum lithium levels or lower systemic toxicity.
The Federal Reserve cut its key interest rate Wednesday by a quarter-point — its third cut this year — but also signaled that it expects to reduce rates more slowly next year than it ...
ALTO-100 is orally active and is administered orally in the form of tablets. [1] Peak levels of ALTO-100 are reached 1 to 2 hours after administration. [1] Area-under-the-curve levels of ALTO-100 increase linearly across a dosing range of 40 mg one to three times per day (i.e., 40–120 mg/day). [1]
Instead of reaping the benefits of Gatorade, it can lead to consuming too much sugar, which can negatively impact the body in many ways, including increasing the risk for type 2 diabetes, obesity ...
Lithium ion (Li +) is used in psychiatry for the treatment of mania, endogenous depression, and psychosis, and also for treatment of schizophrenia. Usually lithium carbonate (Li 2 CO 3) is applied, but sometimes lithium citrate (Li 3 C 6 H 5 O 7), lithium sulfate or lithium oxy-butyrate are used as alternatives. [12] Li + is not metabolized.