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The human genome codes for 95 non-redundant helicases: 64 RNA helicases and 31 DNA helicases. [2] Many cellular processes, such as DNA replication , transcription , translation , recombination , DNA repair , and ribosome biogenesis involve the separation of nucleic acid strands that necessitates the use of helicases.
A helicase–primase complex (also helicase-primase, Hel/Prim, H-P or H/P) is a complex of enzymes including DNA helicase and DNA primase.A helicase-primase associated factor protein may also be present.
22427 Ensembl ENSG00000165392 ENSMUSG00000031583 UniProt Q14191 O09053 RefSeq (mRNA) NM_000553 NM_001122822 NM_011721 RefSeq (protein) NP_000544 NP_001116294 NP_035851 Location (UCSC) Chr 8: 31.03 – 31.18 Mb Chr 8: 33.72 – 33.88 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Werner syndrome ATP-dependent helicase, also known as DNA helicase, RecQ-like type 3, is an enzyme that ...
DnaB helicase is an enzyme in bacteria which opens the replication fork during DNA replication.Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerisation of the N-terminal domain has been observed and may occur during the enzymatic cycle. [1]
DEAD box proteins are involved in an assortment of metabolic processes that typically involve RNAs, but in some cases also other nucleic acids. [2] They are highly conserved in nine motifs and can be found in most prokaryotes and eukaryotes, but not all.
RecQ helicase is a family of helicase enzymes initially found in Escherichia coli [1] that has been shown to be important in genome maintenance. [2] [3] [4] They function through catalyzing the reaction ATP + H 2 O → ADP + P and thus driving the unwinding of paired DNA and translocating in the 3' to 5' direction.
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