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The cancer treatment drug topotecan is a synthetic chemical compound similar in chemical structure to camptothecin which is found in extracts of Camptotheca (happy tree). [7] Catharanthus roseus. Vinca alkaloids were originally manufactured by extracting them from Catharanthus roseus (Madagascar Periwinkle). [1] Podophyllum spp.
Numbering over 4,000 distinct chemical structures mostly from plants, such polyphenols have not been demonstrated to be antioxidants in vivo. [1] [2] [3] In vitro at high experimental doses, polyphenols may affect cell-to-cell signaling, receptor sensitivity, inflammatory enzyme activity or gene regulation.
The Journal of Internal medicine published a paper in 2007 which reviews 41 studies conducted concerning Vitamin C and Vitamin E and their role in cancer prevention and treatment. Thirty eight studies did show statistically insufficient beneficial effects of Vitamin E and C on cancer patients.
The free radical theory of aging states that organisms age because cells accumulate free radical damage over time. [1] A free radical is any atom or molecule that has a single unpaired electron in an outer shell. [2] While a few free radicals such as melanin are not chemically reactive, most biologically relevant free radicals are highly ...
[3] [4] [5] By non-antioxidant mechanisms still undefined, polyphenols may affect mechanisms of cardiovascular disease or cancer. [ 6 ] The increase in antioxidant capacity of blood seen after the consumption of polyphenol-rich (ORAC-rich) foods is not caused directly by the polyphenols, but most likely results from increased uric acid levels ...
As an example of a result of the preferential treatment, the US diet delivers approximately 70 mg/d of γ-tocopherol, and plasma concentrations are on the order of 2–5 μmol/L; meanwhile, dietary α-tocopherol is about 7 mg/d, but plasma concentrations are in the range of 11–37 μmol/L. [14] Affinity of α-TTP for vitamin E vitamers [14]
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