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The stratum compactum is the comparatively deeper, more compacted and more cohesive part of the stratum corneum. [6] The corneocytes of the stratum disjunctum are larger, more rigid and more hydrophobic than those of the stratum compactum. [7] Research on osmotic permeability suggests the stratum compactum consists of two layers.
After reaching the top layer stratum corneum they are eventually 'sloughed off', or desquamated. This process is called keratinization and takes place within weeks. It was previously believed that the stratum corneum was "a simple, biologically inactive, outer epidermal layer comprising a fibrillar lattice of dead keratin". [9]
The lipids ultimately form the lamellar lipid bilayer that surrounds corneocytes and also contributes to the permeability barrier homeostasis of the stratum corneum. [12] The homeostasis function is regulated by the calcium gradient in the epidermis. [17] Usually the calcium level is very low in stratum corneum, but high in stratum granulosum.
In normal skin, the rate of keratinocyte production equals the rate of loss, [4] taking about two weeks for a cell to journey from the stratum basale to the top of the stratum granulosum, and an additional four weeks to cross the stratum corneum. [2] The entire epidermis is replaced by new cell growth over a period of about 48 days. [13]
The forearm is the region of the upper limb between the elbow and the wrist. [1] The term forearm is used in anatomy to distinguish it from the arm , a word which is used to describe the entire appendage of the upper limb, but which in anatomy, technically, means only the region of the upper arm, whereas the lower "arm" is called the forearm.
Hyperkeratosis is thickening of the stratum corneum (the outermost layer of the epidermis, or skin), often associated with the presence of an abnormal quantity of keratin, [1] and is usually accompanied by an increase in the granular layer. As the corneum layer normally varies greatly in thickness in different sites, some experience is needed ...
The anterior compartment of the arm is also known as the flexor compartment of the arm as its main action is that of flexion. The anterior compartment is one of the two anatomic compartments of the upper arm, the other being the posterior compartment. The compartment contains three muscles; the biceps brachii, the brachialis and the ...
68668 Ensembl ENSG00000167754 ENSMUSG00000074155 UniProt Q9Y337 n/a RefSeq (mRNA) NM_001077491 NM_001077492 NM_012427 NM_026806 RefSeq (protein) NP_001070959 NP_001070960 NP_036559 n/a Location (UCSC) Chr 19: 50.94 – 50.95 Mb Chr 7: 43.49 – 43.5 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Kallikrein-5, formerly known as stratum corneum tryptic enzyme (SCTE), is a serine ...