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Phosphatidylserine (abbreviated Ptd-L-Ser or PS) is a phospholipid and is a component of the cell membrane. [1] It plays a key role in cell cycle signaling, specifically in relation to apoptosis . It is a key pathway for viruses to enter cells via apoptotic mimicry . [ 2 ]
Animal studies have shown that the drug also affects ovarian, [58] liver, stomach, [59] prostate, and breast cancers, [60] as well as gliomas [61] and pancreatic cancer (in combination with parthenolide). [62] However, attempts to use arsenic trioxide in the treatment of solid tumors have been limited by the drug's toxicity. [63]
The prostate gets larger in most men as they get older. For a symptom-free man of 46 years, the risk of developing BPH over the next 30 years is 45%. Incidence rates increase from 3 cases per 1000 man-years at age 45–49 years, to 38 cases per 1000 man-years by the age of 75–79 years.
Intrinsic kidney diseases are the classic diseases of the kidney including drug toxicity and nephritis. Post-renal kidney failure is outlet obstruction after the kidney, such as a kidney stone or prostatic bladder outlet obstruction. Kidney failure may require medication, dietary lifestyle modifications, and dialysis.
In a 2023 review of research on supplementation with NAD-boosting compounds, researchers found that the supplements were safe and tolerable in healthy, middle-aged and older adults.
In the longer term, treatment depends on the cause. BPH may respond to alpha blocker and 5-alpha-reductase inhibitor therapy, or surgically with prostatectomy or transurethral resection of the prostate (TURP). [citation needed] Use of alpha-blockers can provide relief of urinary retention following de-catheterization for both men and women.