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This microRNA database and microRNA targets databases is a compilation of databases and web portals and servers used for microRNAs and their targets. MicroRNAs (miRNAs) represent an important class of small non-coding RNAs (ncRNAs) that regulate gene expression by targeting messenger RNAs. [1]
miR-632 targets the coding region of the DNAJB6 protein, a member of the Heat Shock Protein 40 (HSP40) family which shows constitutive expression. DNAJB6 is known to be a negative regulator of tumour progression in breast cancer and its levels are compromised in advanced tumour progression. miR-632 has been linked to be downregulation of DNAJB6 and is capable of silencing both spliced variants ...
miRBase grew from the microRNA registry resource set up by Sam Griffiths-Jones in 2003. [7] According to Ana Kozomara and Sam Griffiths-Jones miRBase has five aims: [1] To provide a consistent naming system for microRNAs; To provide a central place collecting all known microRNA sequences; To provide human and computer readable information for ...
And it has been suggested that deregulation of this miRNA can lead to the expression of mental disorders such as schizophrenia. [3] Recent findings show that miR-219 is linked with Tau toxicity, suggesting that miR-219 is involved in neurodegenerative disease, such as Alzheimer's disease, Parkinson's disease etc. [ 4 ]
The mir-BART2 microRNA precursor found in Human herpesvirus 4 (Epstein–Barr virus) and Cercopithicine herpesvirus 15. mir-BART2 is expressed in all stages of infection but expression is significantly elevated in the lytic stage.
Oncomir-1 has 2 paralogs, miR-106a-363 and mir-106b-25. These are located on different chromosomes and contain individual miRNAs that are highly similar to those encoded by the mir-17-92 cluster. [7] Mir-92-1 for example, appears on the mir-17-92 cluster and mir-92-2 appears on the mir-106a-363 cluster.
The microRNA precursor miR-17 family, includes miR-20a/b, miR-93, and miR-106a/b. With the exception of miR-93, these microRNAs are produced from several microRNA gene clusters, which apparently arose from a series of ancient evolutionary genetic duplication events, and also include members of the miR-19, and miR-25 families. [1]
The miR-15 microRNA precursor family is made up of small non-coding RNA genes that regulate gene expression. The family includes the related mir-15a and mir-15b sequences, as well as miR-16-1, miR-16-2, miR-195 and miR-497. These six highly conserved miRNAs are clustered on three separate chromosomes. [1]