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Conjugated estrogens/methyltestosterone (CEEs/MT), sold under the brand name Premarin with Methyltestosterone, is a combination of conjugated estrogens (CEEs), an estrogen, and methyltestosterone (MT), an androgen and anabolic steroid (AAR), which is used in menopausal hormone therapy for women.
This is a complete list of estrogens and formulations that are approved by the FDA Tooltip Food and Drug Administration and available in the United States. Estrogens are used as hormonal contraceptives , in hormone replacement therapy , and in the treatment of gynecological disorders .
Estrogens, conjugated is the generic name of the drug and its USP Tooltip United States Pharmacopeia and JAN Tooltip Japanese Accepted Name. [87] It is also known as conjugated estrogens or as conjugated equine estrogens. [10] [unreliable medical source?] The brand name Premarin is a contraction of "pregnant mares' urine". [88] [89] [90]
Unlike other medications like progestins and anabolic steroids, estrogens do not have other hormonal activities. [1] Estrogens also have antigonadotropic effects and at sufficiently high dosages can strongly suppress sex hormone production. [1] Estrogens mediate their contraceptive effects in combination with progestins by inhibiting ovulation.
Average number of moderate-to-severe hot flashes per week with placebo and different doses of oral estradiol in menopausal women [40] [41]. Estradiol is used in menopausal hormone therapy to prevent and treat moderate to severe menopausal symptoms such as hot flashes, vaginal dryness and atrophy, and osteoporosis (bone loss). [11]
[3] [4] [11] Premarin was introduced by Ayerst in 1941 [4] and has become not only a very widely used estrogen, but one of the most widely prescribed drugs in North America. [12] Both Emmenin and Progynon contained a mixture of water-soluble conjugated estrogens, later determined to be mostly estriol glucuronide.
Esterified estrogens (EEs), sold under the brand names Estratab and Menest among others, is an estrogen medication which is used hormone therapy for menopausal symptoms and low sex hormone levels in women, to treat breast cancer in both women and men, and to treat prostate cancer in men.
Ethinylestradiol (EE) is an estrogen medication which is used widely in birth control pills in combination with progestins. [7] [8] In the past, EE was widely used for various indications such as the treatment of menopausal symptoms, gynecological disorders, and certain hormone-sensitive cancers.