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After one year on the ketogenic diet, the success rate (seizure reduction over 50%) is between 30 and 50% and the dropout rate is around 45%. [32] [33] Although the ketogenic diet can be very effective, some families report that it's not compatible with daily life given its restrictive nature. It can be especially difficult for adolescents to ...
By 2007, the ketogenic diet was available from around 75 centres in 45 countries, and less restrictive variants, such as the modified Atkins diet, were in use, particularly among older children and adults. The ketogenic diet was also under investigation for the treatment of a wide variety of disorders other than epilepsy. [1]
A ketogenic diet is a diet that causes ketosis, a state in which there is an increased amount of ketones in the body. Adopting and maintaining rigid diet may be difficult for some families. Short-term ketogenic diet might be associated with nonsignificant decreases in frequency of parent-reported seizures in children with LGS. [35]
The effects of sustaining ketosis for up to two years are known from studies of people following a strict ketogenic diet for epilepsy or type 2 diabetes; these include short-term adverse effects leading to potential long-term ones. [20] However, literature on longer term effects of intermittent ketosis is lacking. [20]
A diet high in fats and low in carbohydrates may also be beneficial, known as a ketogenic diet. Although diet adjustment can help, it does not eliminate the symptoms. Until a better form of treatment or cure is discovered, those with this disease will have myoclonic epilepsy for the rest of their lives. [6]
Russell Morse Wilder Sr. (November 24, 1885 – December 16, 1959) [1] was an American physician, diabetologist, epileptologist, and medical researcher, known as one of the originators of the ketogenic ("classic keto") diet as a therapy for both epilepsy [2] [3] and diabetes. [4] [5] He coined the term "ketogenic diet."
A 2022 systematic review of the literature has found some evidence to support that a ketogenic diet or modified Atkins diet can be helpful in the treatment of epilepsy in some infants. [168] These types of diets may be beneficial for children with drug-resistant epilepsy; the use for adults remains uncertain. [6]
The seizures are often resistant to treatment. [2] High doses of benzodiazepines or barbiturates are often used, with care taking place in the intensive care unit. [2] A ketogenic diet may help in some cases. [1] The medications anakinra or tocilizumab have been tried. [2] The risk of death, despite treatment is about 12%. [2]