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Isoelectronicity is a phenomenon observed when two or more molecules have the same structure (positions and connectivities among atoms) and the same electronic configurations, but differ by what specific elements are at certain locations in the structure. For example, CO, NO +, and N 2 are isoelectronic, while CH 3 COCH 3 and CH 3 N = NCH 3 are ...
The manufacturers of the affected products became aware of the contamination but continued to sell it. After the contaminated products were banned in many developed countries, sales were shifted to developing markets. 1982 Chicago Tylenol murders: Tylenol pain-relief capsules were laced with potassium cyanide, leading to seven deaths. [5]
In drug discovery, either a large series of structural analogs of an initial lead compound are created and tested as part of a structure–activity relationship study [5] or a database is screened for structural analogs of a lead compound. [6] Chemical analogues of illegal drugs are developed and sold in
An "incident" of chemical food contamination may be defined as an episodic occurrence of adverse health effects in humans (or animals that might be consumed by humans) following high exposure to particular chemicals, or instances where episodically high concentrations of chemical hazards were detected in the food chain and traced back to a particular event.
Drug Manufacturer Indication Avacincaptad pegol: To treat geographic atrophy secondary to age-related macular degeneration [4] Cipaglucosidase alfa: To treat late-onset Pompe disease with miglustat [4] Dabrafenib: Dostarlimab: Eflornithine: Elranatamab: To treat relapsed or refractory multiple myeloma after at least four lines of therapy [4 ...
The following are settlements reached with US authorities against pharmaceutical companies to resolve allegations of "off-label" promotion of drugs. Under the Federal Food, Drug, and Cosmetic Act, it is illegal for pharmaceutical companies to promote their products for uses not approved by the Food and Drug Administration (FDA), and corporations that market drugs for off-label indications may ...
In the United States, medical and food test products are regulated by the Food and Drug Administration (FDA). [1] [2]Title 21 "Food and Drugs" , Part 50 "Protection of Human Subjects" defines test article as "drug (including a biological product for human use), medical device for human use, human food additive, color additive, electronic product, or any other article subject to regulation ...
For example, a chloride -Cl group may often be replaced by a trifluoromethyl -CF 3 group or by a cyano -C≡N group. Depending on the particular molecule used, the substitution may result in little change in activity, or either increased or decreased affinity or efficacy - depending on what factors are important for ligand binding to the target ...