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Enterovirus D68 (EV-D68) is a member of the Picornaviridae family, an enterovirus. First isolated in California in 1962 and once considered rare, it has been on a worldwide upswing in the 21st century. [2] [3] [4] It is suspected of causing a polio-like disorder called acute flaccid myelitis (AFM).
Enterovirus is a genus of positive-sense single-stranded RNA viruses associated with several human and mammalian diseases. Enteroviruses are named by their transmission-route through the intestine ('enteric' meaning intestinal).
Coxsackie B infections usually do not cause serious disease, although for newborns in the first 1–2 weeks of life, Coxsackie B infections can easily be fatal. [2] The pancreas is a frequent target, which can cause pancreatitis. [2] Coxsackie B3 (CB3) infections are the most common enterovirus cause of myocarditis and sudden cardiac death. [8]
Coxsackieviruses are divided into group A and group B viruses based on early observations of their pathogenicity in neonatal mice. [1] Group A coxsackieviruses were noted to cause a flaccid paralysis (which was caused by generalized myositis) while group B coxsackieviruses were noted to cause a spastic paralysis (due to focal muscle injury and degeneration of neuronal tissue).
The Annual Review of Pathology: Mechanisms of Disease is a peer-reviewed academic journal that publishes an annual volume of review articles relevant to pathology. It was established in 2006 and is published by Annual Reviews. Its co-editors have been Jon C. Aster, Mel B. Feany, and Jayanta Debnath since 2021.
Enterovirus E The virus may also be referred to as enteric cytopathic bovine orphan virus (ECBO). It is endemic in cattle populations worldwide, and although normally fairly nonpathogenic, it can cause reproductive, respiratory, or enteric disease – particularly when the animal is concurrently infected with another pathogen.
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Enterovirus D is a species of enterovirus which causes disease in humans. Five subtypes have been identified to date: Five subtypes have been identified to date: Enterovirus 68 : causes respiratory disease, and is associated with acute flaccid paralysis (AFP) – a disease similar to polio .