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Hyaluronic acid is a polymer of disaccharides, which are composed of D-glucuronic acid and N-acetyl-D-glucosamine, linked via alternating β-(1→4) and β-(1→3) glycosidic bonds. Hyaluronic acid can be 25,000 disaccharide repeats in length. Polymers of hyaluronic acid can range in size from 5,000 to 20,000,000 Da in vivo.
Polysaccharide-based hydrogel dressings have been synthesized from polymers such as hyaluronic acid, chitin, chitosan, alginate, and agarose. [ 1 ] [ 40 ] [ 47 ] [ 48 ] [ 49 ] Naturally-derived protein/proteoglycan hydrogel dressings have been synthesized from polymers such as collagen , gelatin , kappa-carrageenan, and fibrin .
Solesta is the marketed brand name of a system of injections of dextranomer in stabilized sodium hyaluronate for use in fecal incontinence (FI). [5] This preparation is a biocompatible gel, for use as a perianal injectable bulking agent.
Gelclair is a medicinal oral gel containing polyvinylpyrrolidone (PVP) and hyaluronic acid [1] that coats the surface of the mouth forming a thin protective film over painful oral lesions, such as those caused by radiotherapy or chemotherapy treatment for cancer.
Becaplermin is used for the treatment of diabetic foot ulcers. [2] Studies of becaplermin showed that when used with good wound care, complete healing significantly increased and the ulcers healed on average 6 weeks faster. [3] Pharmacoeconomic studies reinforce the cost effectiveness of becaplermin as an adjunct to good wound care. [4]
Though it's best known in the world of skincare, hyaluronic acid is a superstar ingredient in many hydrating hair products. Here, experts break down its benefits, side effects, and how to use it.