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The fluorescent treponemal antibody absorption (FTA-ABS) test is a diagnostic test for syphilis.Using antibodies specific for the Treponema pallidum species, such tests would be assumed to be more specific than non-treponemal testing such as VDRL but have been shown repeatedly to be sensitive but not specific for the diagnosis of neurosyphilis in cerebrospinal fluid (CSF).
Congenital syphilis is syphilis that occurs when a mother with untreated syphilis passes the infection to her baby during pregnancy or at birth. [4] It may present in the fetus, infant, or later. [1] [5] Clinical features vary and differ between early onset, that is presentation before 2-years of age, and late onset, presentation after age 2 ...
The rapid plasma reagin test (RPR test or RPR titer) is a type of rapid diagnostic test that looks for non-specific antibodies in the blood of the patient that may indicate an infection by syphilis or related non-venereal treponematoses. It is one of several nontreponemal tests for syphilis (along with the Wassermann test and the VDRL test).
Nontreponemal tests are screening tests, very rapid and relatively simple, but need to be confirmed by treponemal tests. [1] Centers for Disease Control and Prevention (CDC)-approved standard tests include the VDRL test (a slide test), the rapid plasma reagin (RPR) test (a card test), the unheated serum reagin (USR) test, and the toluidine red ...
Latent syphilis has no symptoms and can last years. [2] In tertiary syphilis, there are gummas (soft, non-cancerous growths), neurological problems, or heart symptoms. [3] Syphilis has been known as "the great imitator", because it may cause symptoms similar to many other diseases. [2] [3] Syphilis is most commonly spread through sexual ...
Treponema pallidum, formerly known as Spirochaeta pallida, is a microaerophilic, gram-negative, spirochaete bacterium with subspecies that cause the diseases syphilis, bejel (also known as endemic syphilis), and yaws. [1] It is known to be transmitted only among humans and baboons. [2]
Therefore, before seroconversion, the serological assay will not detect any antibody, and the individual's serostatus is seronegative for the antibody. After seroconversion, sufficient concentration of the specific antibody exists in the blood, and the serological assay will detect the antibody. The individual is now seropositive for the antibody.
Syphilis prevalence dropped to an all-time low by 1955. A total of 6993 cases of primary and secondary syphilis were recorded in 1998, the lowest number since 1941. [87] In 2000 and 2001 in the United States, the national rate of reported primary and secondary syphilis cases was 2.1 cases per 100,000 population (6103 cases reported).