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An abortive serotonin syndrome state, in which some but not all of the symptoms of the full serotonin syndrome are present, has been reported with venlafaxine at mid-range dosages (150 mg per day). [46] A case of a patient with serotonin syndrome induced by low-dose venlafaxine (37.5 mg per day) has also been reported. [47]
At moderate doses (>150 mg/day), it acts on serotonergic and noradrenergic systems, whereas at high doses (>300 mg/day), it also affects dopaminergic neurotransmission. [22] At small doses, venlafaxine has also been shown to be effective in treating vasomotor symptoms (hot flashes and night sweats) of menopause. [21]
The recommended maximum daily dose of citalopram and escitalopram was reduced due to concerns with QT prolongation. [93] [94] [95] In overdose, fluoxetine has been reported to cause sinus tachycardia, myocardial infarction, junctional rhythms, and trigeminy.
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The dose should be increased after a minimum of 3 days up to approximately 1.2 mg/kg daily (target dose) as a single or two divided doses (in the morning and late afternoon). For children older than 6 years old, over 70 kg, acute treatment should be started with 40 mg/day orally and increased up to 80 mg/day after a minimum of 3 days.
If you’re tapering off antidepressants or recently skipped a dose or two, you may have experienced a mysterious side effect commonly known as “brain zaps.” ... Dr. Gold says, like Effexor ...
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