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Prolactin-releasing hormone, also known as PRLH, is a hypothetical human hormone or hormone releasing factor.Existence of this factor has been hypothesized as prolactin is the only currently known hormone for which almost exclusively negative regulating factors are known (such as dopamine, leukemia inhibitory factor, some prostaglandins) but few stimulating factor.
Prolactin-releasing peptide (PrRP) is a peptide hormone that in humans is encoded by the PRLH gene. [5] PrRP stimulates prolactin (PRL) release and regulates the expression of prolactin through binding to the prolactin-releasing peptide receptor (GPR10).
Prolactin has a wide variety of effects. It stimulates the mammary glands to produce milk (): increased serum concentrations of prolactin during pregnancy cause enlargement of the mammary glands and prepare for milk production, which normally starts when levels of progesterone fall by the end of pregnancy and a suckling stimulus is present.
Prolactin (or leuteotropic hormone) PRL Peptide: anterior pituitary, uterus: lactotrophs of anterior pituitary Decidual cells of uterus: PRL receptor: milk production in mammary glands sexual gratification after sexual acts: 54 Prolactin-releasing hormone: PRLH Peptide: hypothalamus: Release prolactin from anterior pituitary: 55 Relaxin: RLN ...
Physiological (i.e., non-pathological) causes that can increase prolactin levels include: ovulation, pregnancy, breastfeeding, chest wall injury, stress, stress-associated REM sleep, and exercise. [20] [4] [21] During pregnancy, prolactin increases can range up to 600 ng/mL, depending on estrogen and progesterone concentrations. After delivery ...
A prolactin cell (also known as a lactotropic cell, epsilon acidophil, lactotrope, lactotroph, mammatroph, mammotroph) is a cell in the anterior pituitary which produces prolactin (a peptide hormone) in response to hormonal signals including dopamine (which is inhibitory), thyrotropin-releasing hormone and estrogen (especially during pregnancy), which are stimulatory.
It modifies the metabolic state of the mother during pregnancy to facilitate energy supply to the fetus. hPL has anti-insulin properties. hPL is a hormone secreted by the syncytiotrophoblast during pregnancy. Like human growth hormone, hPL is encoded by genes on chromosome 17q22-24. It was identified in 1963. [2]
Prolactin, a major hormone of the HPP axis.. The hypothalamic–pituitary–prolactin axis (HPP axis), also known as the hypothalamic–pituitary–mammary axis or hypothalamic–pituitary–breast axis, is a hypothalamic–pituitary axis which includes the secretion of prolactin (PRL; luteotropin) from the lactotrophs of the pituitary gland into the circulation and the subsequent action of ...