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  2. Insulin-like growth factor 1 - Wikipedia

    en.wikipedia.org/wiki/Insulin-like_growth_factor_1

    IGF-1 then stimulates systemic body growth, and has growth-promoting effects on almost every cell in the body, especially skeletal muscle, cartilage, bone, liver, kidney, nerve, skin, hematopoietic, and lung cells. In addition to the insulin-like effects [further explanation needed], IGF-1 can also regulate cellular DNA synthesis. [21]

  3. Insulin - Wikipedia

    en.wikipedia.org/wiki/Insulin

    Insulin is a peptide hormone containing two chains cross-linked by disulfide bridges. Insulin (/ ˈ ɪ n. sj ʊ. l ɪ n /, [5] [6] from Latin insula, 'island') is a peptide hormone produced by beta cells of the pancreatic islets encoded in humans by the insulin (INS) gene. It is the main anabolic hormone of the body. [7]

  4. Growth hormone - Wikipedia

    en.wikipedia.org/wiki/Growth_hormone

    In addition to increasing height in children and adolescents, growth hormone has many other effects on the body: Increases calcium retention, [41] [citation needed] and strengthens and increases the mineralization of bone; Increases muscle mass through sarcomere hypertrophy; Promotes lipolysis; Increases protein synthesis

  5. Leptin - Wikipedia

    en.wikipedia.org/wiki/Leptin

    This insulin-leptin relationship is notably similar to insulin's effect on the increase of IL-6 gene expression and secretion from preadipocytes in a time- and dose-dependent manner.) [83] Furthermore, plasma leptin concentrations have been observed to gradually increase when acipimox is administered to prevent lipolysis, concurrent hypocaloric ...

  6. Insulin signal transduction pathway - Wikipedia

    en.wikipedia.org/wiki/Insulin_signal...

    The effects of insulin vary depending on the tissue involved, e.g., insulin is most important in the uptake of glucose by muscle and adipose tissue. [2] This insulin signal transduction pathway is composed of trigger mechanisms (e.g., autophosphorylation mechanisms) that serve as signals throughout the cell. There is also a counter mechanism in ...

  7. Insulin-like growth factor 1 receptor - Wikipedia

    en.wikipedia.org/wiki/Insulin-like_growth_factor...

    The insulin-like growth factor 1 (IGF-1) receptor is a protein found on the surface of human cells. It is a transmembrane receptor that is activated by a hormone called insulin-like growth factor 1 and by a related hormone called IGF-2. It belongs to the large class of tyrosine kinase receptors. This receptor mediates the effects of IGF-1 ...

  8. Insulin-like growth factor - Wikipedia

    en.wikipedia.org/wiki/Insulin-like_growth_factor

    Insulin-like growth factor 2 (IGF-2, at times IGF-II) is thought to be a primary growth factor required for early development while IGF-1 expression is required for achieving maximal growth. Gene knockout studies in mice have confirmed this, though other animals are likely to regulate the expression of these genes in distinct ways.

  9. Carbohydrate–insulin model - Wikipedia

    en.wikipedia.org/wiki/Carbohydrateinsulin_model

    According to the carbohydrate–insulin model, low-carbohydrate diets would be the most effective in causing long-term weight loss. Notable proponents of the carbohydrate–insulin model include Gary Taubes and David Ludwig. [1] [2] The CIM has been tested in mice [3] and humans. [4]