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Digitoxin is a cardiac glycoside used for the treatment of heart failure and certain kinds of heart arrhythmia. It is a phytosteroid and is similar in structure and effects to digoxin, though the effects are longer-lasting. Unlike digoxin, which is eliminated from the body via the kidneys, it is eliminated via the liver, and so can be used in ...
Digoxin is in the cardiac glycoside family of medications. [4] It was first isolated in 1930 from the foxglove plant, Digitalis lanata. [7] [8] It is on the World Health Organization's List of Essential Medicines. [9] In 2021, it was the 241st most commonly prescribed medication in the United States, with more than 1 million prescriptions. [10 ...
Gitoformate is a derivative of the glycoside gitoxin, with five of the six free hydroxyl groups formylated, one on the aglycon and four on the sugar. [2] [3] Gitoxin, a cardiac glycoside from the woolly foxglove (Digitalis lanata), has an aglycon of the cardenolide type named gitoxigenin, which is also the aglycon of lanatoside B, another Digitalis lanata glycoside.
Cardiac glycosides like digoxin, primarily inhibit the sodium-potassium pump (Na+/K+ ATPase), an important protein located on the surface of cardiomyocytes (cardiac muscle cells). [ 1 ] [ 2 ] Using ATP (the cell’s energy currency), this protein facilitates the transport of extracellular potassium ions (K+) into the cell while exporting sodium ...
Digitalis ciliata, commonly called hairy foxglove is a member of the genus Digitalis. [1] It has thimble-shaped, yellow to cream-colored flowers produced on perennial plants with evergreen foliage. It is native to the Caucasus and is grown as an ornamental plant in other parts of the world. The species name is derived from the fine hairs that ...
Deslanoside (trade name Cedilanide in Brazil [1]) is a cardiac glycoside, a type of drug that can be used in the treatment of congestive heart failure and cardiac arrhythmia (irregular heartbeat). It is found in the leaves of Digitalis lanata , the Woolly Foxglove.
Lanatoside C (or isolanid) is a cardiac glycoside, a type of drug that can be used in the treatment of congestive heart failure and cardiac arrhythmia (irregular heartbeat). Lanatoside C can be used orally [1] or by the intravenous route. [2] It is marketed in a number of countries and is also available in generic form. [3]
α-Acetyldigoxin is a cardiac glycoside found in plants of the genus Digitalis, including Digitalis lanata. [1] It is an acetyl derivative of digoxin and an isomer of β-acetyldigoxin . α-Acetyldigoxin increases the contractility of the heart by its positive inotropic effect on cardiac muscle .