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Digoxin is in the cardiac glycoside family of medications. [4] It was first isolated in 1930 from the foxglove plant, Digitalis lanata. [7] [8] It is on the World Health Organization's List of Essential Medicines. [9] In 2021, it was the 241st most commonly prescribed medication in the United States, with more than 1 million prescriptions. [10 ...
For example, in 2008 US poison centers reported 2,632 cases of digoxin toxicity, and 17 cases of digoxin-related deaths. [18] Because cardiac glycosides affect the cardiovascular, neurologic, and gastrointestinal systems, these three systems can be used to determine the effects of toxicity.
Mechanism of action of cardiac glycosides (Digitalis): inhibition of Na+/K+ ATPase. Cardiac glycosides like digoxin, primarily inhibit the sodium-potassium pump (Na+/K+ ATPase), an important protein located on the surface of cardiomyocytes (cardiac muscle cells).
These glycosides are found in the plant genera Digitalis, Scilla, and Strophanthus. They are used in the treatment of heart diseases, e.g., congestive heart failure (historically as now recognised does not improve survivability; other agents [example needed] are now preferred [medical citation needed]) and arrhythmia.
Digitalis purpurea drawings by Franz Köhler. Depending on the species, the digitalis plant may contain several deadly physiological and chemically related cardiac and steroidal glycosides. Thus, the digitalis plants have earned several, more sinister, names: dead man's bells and witch's gloves. The toxins can be absorbed via the skin [37] or ...
Digitoxin is a cardiac glycoside used for the treatment of heart failure and certain kinds of heart arrhythmia. It is a phytosteroid and is similar in structure and effects to digoxin, though the effects are longer-lasting. Unlike digoxin, which is eliminated from the body via the kidneys, it is eliminated via the liver, and so can be used in ...
Digitalis lanata contains a powerful cardiac glycoside that may be used by patients with heart conditions. Digoxin (digitalin) is a drug that is extracted from D. lanata. [17] [18] It is used to treat some heart conditions such as atrial fibrillation and cardiac arrhythmias. [18]
Digitoxin, a phytosteroid and cardiac glycoside found in digitalis. Phytosteroids, also known as plant steroids, are naturally occurring steroids that are found in plants. [1] Examples include digoxin, digitoxin, diosgenin, and guggulsterone, as well as phytosterols like β-sitosterol and other phytoestrogens like isoflavones. [1]