Search results
Results From The WOW.Com Content Network
Gelsolin is an actin-binding protein that is a key regulator of actin filament assembly and disassembly.Gelsolin is one of the most potent members of the actin-severing gelsolin/villin superfamily, as it severs with nearly 100% efficiency.
Actin-binding proteins (also known as ABPs) are proteins that bind to actin. [1] This may mean ability to bind actin monomers, or polymers, or both. Many actin-binding proteins, including α-actinin, β-spectrin, dystrophin, utrophin and fimbrin, do this through the actin-binding calponin homology domain .
Actin-binding proteins regulate assembly and disassembly of actin filaments. [4] Cofilin, a member of the ADF/cofilin family is actually a protein with 70% sequence identity to destrin, making it part of the ADF/cofilin family of small ADP-binding proteins. [5] [6] The protein binds to actin monomers and filaments, G actin and F actin ...
Profilin is an actin-binding protein involved in the dynamic turnover and reconstruction of the actin cytoskeleton. [1] It is found in most eukaryotic organisms. Profilin is important for spatially and temporally controlled growth of actin microfilaments, which is an essential process in cellular locomotion and cell shape changes.
The proline-rich domain interacts with profilin, a protein that catalyses nucleotide exchange on G-actin monomers and promotes addition to barbed ends of filamentous F-actin. [6] Since CAP can bind profilin via a proline-rich domain, and G-actin via a C-terminal domain, it has been suggested that a ternary G-actin/CAP/profilin complex could be ...
Together, these two proteins comprise one of the four classes of G protein alpha subunits. [2] G protein alpha subunits bind to guanine nucleotides and function in a regulatory cycle, and are active when bound to GTP but inactive and associated with the G beta-gamma complex when bound to GDP. [3] [4] G 12 /G 13 are not targets of pertussis ...
Cytoskeletal drugs are small molecules that interact with actin or tubulin.These drugs can act on the cytoskeletal components within a cell in three main ways. Some cytoskeletal drugs stabilize a component of the cytoskeleton, such as taxol, which stabilizes microtubules, or Phalloidin, which stabilizes actin filaments.
Villin-1 is a 92.5 kDa tissue-specific actin-binding protein associated with the actin core bundle of the brush border. [1] Villin-1 is encoded by the VIL1 gene. Villin-1 contains multiple gelsolin -like domains capped by a small (8.5 kDa) "headpiece" at the C-terminus consisting of a fast and independently folding three-helix bundle that is ...