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Chronic liver diseases like chronic hepatitis, chronic alcohol abuse or chronic toxic liver disease may cause liver failure and hepatorenal syndrome; fibrosis and cirrhosis of liver; Cirrhosis may also occur in primary biliary cirrhosis. Rarely, cirrhosis is congenital.
The major causes of hepatic jaundice are significant damage to hepatocytes due to infectious, drug/medication-induced, autoimmune etiology, or less commonly, due to inheritable genetic diseases. [27] The following is a partial list of hepatic causes to jaundice: [28] Acute hepatitis; Chronic hepatitis; Hepatotoxicity; Cirrhosis; Drug-induced ...
Treatment of the condition is specific to the cause of hemolysis, but intense phototherapy and exchange transfusion can be used to help the patient excrete accumulated bilirubin. [11] Complications related to hemolytic jaundice include hyperbilirubinemia and chronic bilirubin encephalopathy, which may be deadly without proper treatment. [12] [13]
Gilbert's syndrome, a genetic disorder of bilirubin metabolism found in a small percent of the population, can cause mild jaundice. [ 14 ] Cirrhosis is the formation of fibrous tissue ( fibrosis ) in the place of liver cells that have died due to a variety of causes, including viral hepatitis, alcohol overconsumption, and other forms of liver ...
Classification and diagnosis of the underlying disease of hyperbilirubinemia are crucial for prescription of treatment. [6] Physical examination reviews clinical symptoms like degree of jaundice, vital signs and sensations of pain, further followed by urine tests, blood analysis and imaging.
Acute liver failure (with hepatocellular necrosis and sinusoidal bleeding) from Marburg virus, a rare cause: Specialty: Gastroenterology, hepatology, intensive care medicine Symptoms: Jaundice, excessive bleeding, altered state of consciousness, hyperdynamic circulation, hepatocellular necrosis, low blood pressure: Complications
The goal of treatment is prevention of hepatocellular carcinoma (HCC). [110] The best way to reduce the long-term risk of HCC is to achieve sustained virological response (SVR). [ 110 ] SVR is defined as an undetectable viral load at 12 weeks after treatment completion and indicates a cure.
Haemolytic jaundice is the commonest cause of pathological jaundice. Those babies with Rh hemolytic disease, ABO incompatibility with the mother, Glucose-6-phosphate dehydrogenase (G-6-PD) deficiency and minor blood group incompatibility are at increased risk of getting haemolytic jaundice. [9]