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Xanomeline is an agonist that primarily targets the muscarinic acetylcholine receptor family of five muscarinic receptor subtypes, which are designated M 1-M 5. [2] While it binds with near identical affinity to all five of the muscarinic receptor subtypes as measured by displacement of a muscarinic radioligand, the preponderance of evidence suggests that xanomeline acts preferentially in the ...
In botany, the theca is related to plant's flower anatomy. The theca of an angiosperm consists of a pair of microsporangia that are adjacent to each other and share a common area of dehiscence called the stomium. [1] Any part of a microsporophyll that bears microsporangia is called an anther. Most anthers are formed on the apex of a filament.
This list of over 500 monoclonal antibodies includes approved and investigational drugs as well as drugs that have been withdrawn from market; consequently, the column Use does not necessarily indicate clinical usage. See the list of FDA-approved therapeutic monoclonal antibodies in the monoclonal antibody therapy page.
Nicergoline, sold under the brand name Sermion among others, is an ergot derivative used to treat senile dementia and other disorders with vascular origins. Internationally it has been used for frontotemporal dementia as well as early onset in Lewy body dementia and Parkinson's dementia.
Opicapone, works to restore the levels of dopamine in the parts of the brain that control movement and coordination. [4] It enhances the effects of levodopa, a precursor of the neurotransmitter dopamine that can be taken by mouth. [4] Opicapone blocks an enzyme that breaks down levodopa in the body called catechol-O-methyltransferase (COMT).
After being referred by their military health care provider and accepted into the treatment program, the service member goes to the NICoE for two to three weeks, where they will stay in a NICoE-dedicated Fisher House on the Bethesda campus. A spouse or other family member may stay with the service member during the time of treatment.
This is a list of major and frequently observed neurological disorders (e.g., Alzheimer's disease), symptoms (e.g., back pain), signs (e.g., aphasia) and syndromes (e.g., Aicardi syndrome). There is disagreement over the definitions and criteria used to delineate various disorders and whether some of these conditions should be classified as ...
Cerliponase alfa, marketed as Brineura, is an enzyme replacement treatment for Batten disease, a neurodegenerative lysosomal storage disease. Specifically, Cerliponase alfa is meant to slow loss of motor function in symptomatic children over three years old with late infantile neuronal ceroid lipofuscinosis type 2 (CLN2).