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Nicotine is unusual in comparison to most drugs, as its profile changes from stimulant to sedative with increasing dosages, a phenomenon known as "Nesbitt's paradox" after the doctor who first described it in 1969. [135] [136] At very high doses it dampens neuronal activity. [137] Nicotine induces both behavioral stimulation and anxiety in ...
A 2011 report in the International Journal of Environmental Research and Public Health (IJERPH) lists 65 carcinogens or possible carcinogens: "Our list of hazardous smoke components includes all nine components reported in mainstream cigarette smoke that are known human carcinogens (IARC Group I carcinogens), as well as all nine components that ...
The LD 50 of nicotine is 50 mg/kg for rats and 3 mg/kg for mice. 0.5–1.0 mg/kg can be a lethal dosage for adult humans, and 0.1 mg/kg for children. [19] [20] However the widely used human LD 50 estimate of 0.5–1.0 mg/kg was questioned in a 2013 review, in light of several documented cases of humans surviving much higher doses; the 2013 review suggests that the lower limit causing fatal ...
"Although nicotine itself is not a carcinogen, we do not know if people who start by using oral nicotine pouches will continue to find them satisfying, or if they will eventually start using more ...
That said, nicotine pouches have a much lower carcinogen burden than cigarettes, Keller-Hamilton says. “For that reason, we expect that smokers who switch to using nicotine pouches would reduce ...
Nicotine products in general have been linked to reproductive harms such as stillbirth, premature birth, and low birth weight. [4] Conversely, non-tobacco-based nicotine pouches (also known as "nic pouches") are classified as non-carcinogenic [5] [6] [7] since nicotine itself is not a carcinogen. However, they are still harmful to ...
[7] [2] [8] [9] See: Health effects of tobacco smoking and List of cigarette smoke carcinogens. Although many of these additives are used in making cigarettes, each cigarette does not contain all of these additives. Some of these additives are found in cigarettes outside the USA too. [10] Some American brands are sold in other nations.
In some cases, nicotine can be detected for up to 12 months. To qualify for non-smoker rates, most life insurance companies require you to be tobacco-free for at least 12 months.