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  2. Clinical trials on glucosamine and chondroitin - Wikipedia

    en.wikipedia.org/wiki/Clinical_trials_on...

    In a follow-up study in 2008, 572 patients from the GAIT trial continued their supplementation for 2 years. After 2 years of supplementation with glucosamine and chondroitin sulfate, alone or in combination, there was no benefit in slowing the loss of cartilage, in terms of joint space width, when compared to a placebo or celecoxib. [29]

  3. Knee arthritis - Wikipedia

    en.wikipedia.org/wiki/Knee_arthritis

    It is not always certain why arthritis of the knee develops. [citation needed] The knee may become affected by almost any form of arthritis, including those related to mechanical damage of the structures of the knee (osteoarthritis, and post-traumatic arthritis), various autoimmune forms of arthritis (including; rheumatoid arthritis, juvenile arthritis, and SLE-related arthritis, psoriatic ...

  4. Chondroitin sulfate - Wikipedia

    en.wikipedia.org/wiki/Chondroitin_sulfate

    Chemical structure of one unit in a chondroitin sulfate chain. Chondroitin-4-sulfate: R 1 = H; R 2 = SO 3 H; R 3 = H. Chondroitin-6-sulfate: R 1 = SO 3 H; R 2, R 3 = H.. Chondroitin sulfate is a sulfated glycosaminoglycan (GAG) [1] composed of a chain of alternating sugars (N-acetylgalactosamine and glucuronic acid).

  5. Glucosamine - Wikipedia

    en.wikipedia.org/wiki/Glucosamine

    Although joint fluid concentrations of glucosamine reached 9–15 μmol/L following intravenous dosing, it was only 0.3–0.7 μmol/L with nasogastric dosing. The authors calculated that these glucosamine synovial fluid levels achieved by the oral route were 500 times lower than that required to have a positive effect on the metabolism of ...

  6. Chondromalacia patellae - Wikipedia

    en.wikipedia.org/wiki/Chondromalacia_patellae

    Chondromalacia patellae (also known as CMP) is an inflammation of the underside of the patella and softening of the cartilage.. The cartilage under the kneecap is a natural shock absorber, and overuse, injury, and many other factors can cause increased deterioration and breakdown of the cartilage.

  7. Joint stiffness - Wikipedia

    en.wikipedia.org/wiki/Joint_stiffness

    Joint stiffness may be either the symptom of pain on moving a joint, the symptom of loss of range of motion or the physical sign of reduced range of motion. Pain on movement is commonly caused by osteoarthritis, often in quite minor degrees, and other forms of arthritis. It may also be caused by injury or overuse and rarely by more complex ...