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Kidney stone disease, also known as renal calculus disease, nephrolithiasis or urolithiasis, is a crystallopathy where a solid piece of material (renal calculus) develops in the urinary tract. [2] Renal calculi typically form in the kidney and leave the body in the urine stream. [2] A small calculus may pass without causing symptoms. [2]
Alkaline citrates are used to prevent recurrent calcium stone formation. [13] [14] [15] [5] This is one of the major types of kidney stones. [16] [17] The citrate salts can increase urine citrate, which binds with urine calcium, reduces supersaturation of calcium salts, and inhibits crystal formation. [18] [8] This helps prevent kidney stones ...
A number of important medical conditions are caused by stones: [citation needed] Nephrolithiasis (kidney stones) Can cause hydronephrosis (swollen kidneys) and kidney failure; Can predispose to pyelonephritis (kidney infections) Can progress to urolithiasis; Urolithiasis (urinary bladder stones) Can progress to bladder outlet obstruction
There are several things to be done to help prevent and treat kidney stones. Skip to main content. 24/7 Help. For premium support please call: 800-290-4726 more ways to reach us. Sign in ...
Biochemically, hippuric acid is produced from benzoic acid and glycine, which occurs in the liver, intestine, and kidneys. [5] In terms of mechanism, benzoic acid is converted to benzoyl CoA, an acylating agent. [6] Hippuric acid may be formed from the essential amino acid phenylalanine through at least two pathways.
Glycine is a required co-agonist along with glutamate for NMDA receptors. In contrast to the inhibitory role of glycine in the spinal cord, this behaviour is facilitated at the glutamatergic receptors which are excitatory. [41] The LD 50 of glycine is 7930 mg/kg in rats (oral), [42] and it usually causes death by hyperexcitability. [citation ...